Yotiao Antibody (7): sc-136177

Yotiao Antibody (7) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Yotiao protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Yotiao antibody (7) is available as the non-conjugated format. Yotiao protein, also known as A-kinase anchoring protein 9 (AKAP9), plays a crucial role in the spatial regulation of signaling pathways within cells. Yotiao (7) antibody localizes to both centrosomes and the Golgi apparatus throughout the cell cycle, which is essential for its function as a scaffolding protein that assembles protein kinases and phosphatases for substrate-specific phosphorylation. This localization allows Yotiao to effectively coordinate the activity of the type II cAMP-dependent protein kinase (PKA) with its substrates, thereby influencing various cellular processes. Yotiao (7) monoclonal antibody interacts with the NR1 subunit of the NMDA receptor, facilitating the cAMP-dependent modulation of NMDA receptor activity at synapses. This interaction is vital for brain development and synaptic plasticity, highlighting the importance of Yotiao in neuronal signaling and function. The unique C-terminus of the Yotiao isoform, which contains an additional 12 amino acid sequence not found in AKAP9, further distinguishes its functional properties. Yotiao is predominantly expressed in the pancreas and skeletal muscle, underscoring its significance in both neuronal and muscle physiology.

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Yotiao Antibody (7) References:

1. Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus.  |  Takahashi, M., et al. 1999. J Biol Chem. 274: 17267-74. PMID: 10358086
2. Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1).  |  Feliciello, A., et al. 1999. FEBS Lett. 464: 174-8. PMID: 10618500
3. Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel.  |  Marx, SO., et al. 2002. Science. 295: 496-9. PMID: 11799244
4. A structural requirement for processing the cardiac K+ channel KCNQ1.  |  Kanki, H., et al. 2004. J Biol Chem. 279: 33976-83. PMID: 15140888
5. Regulatory actions of the A-kinase anchoring protein Yotiao on a heart potassium channel downstream of PKA phosphorylation.  |  Kurokawa, J., et al. 2004. Proc Natl Acad Sci U S A. 101: 16374-8. PMID: 15528278
6. Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue.  |  Saucerman, JJ., et al. 2004. Circ Res. 95: 1216-24. PMID: 15528464
7. Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation.  |  Terrenoire, C., et al. 2005. Circ Res. 96: e25-34. PMID: 15731462