ABCF1 Antibody (C-2): sc-377445

ABCF1 Antibody (C-2) is a mouse monoclonal IgG2b antibody that detects ABCF1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ABCF1 is a crucial protein consisting of 845 amino acids, encoded by the human gene ABCF1, and is a member of the ATP-binding cassette (ABC) transporter family, specifically the EF3 subfamily. Notably, ABCF1 is unique among its counterparts as it lacks the transmembrane domains typically found in most ABC transporters, which positions ABCF1 as a key player in mRNA translation rather than in the transport of molecules across membranes. ABCF1 interacts with eukaryotic initiation factor 2 (eIF2) and is associated with ribosomes, highlighting ABCF1′s significant role in the regulation of protein synthesis. ABCF1 is ubiquitously expressed and can be induced by tumor necrosis factor (TNF), indicating ABCF1′s involvement in cellular responses to stress and inflammation. Furthermore, upon DNA damage, ABCF1 undergoes phosphorylation by either ataxia-telangiectasia mutated (ATM) or ataxia-telangiectasia and Rad3-related (ATR) kinases, which may influence ABCF1′s function in cellular repair mechanisms. anti-ABCF1 antibody (C-2) is an essential tool for researchers investigating the multifaceted roles of ABCF1 in various biological processes and disease states.

The preferred ABCF1 antibody is ABCF1 Antibody (H-3): sc-377185.