SLC19A1 Antibody (D-6): sc-271276
- SLC19A1 Antibody (D-6) is a mouse monoclonal IgG2b κ SLC19A1 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 476-509 at the C-terminus of SLC19A1 of mouse origin
- SLC19A1 Antibody (D-6) is recommended for detection of SLC19A1 of mouse origin by WB, IP, IF and ELISA
- Anti-SLC19A1 Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of SLC19A1 (D-6): sc-271276.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SLC19A1 Antibody (D-6) for WB applications. These reagents are now offered in bundles with SLC19A1 Antibody (D-6) (see ordering information below).
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SEE ALSO...
SLC19A1 Antibody (D-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects SLC19A1 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SLC19A1 antibody (D-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SLC19A1, also known as solute carrier family 19 member 1, reduced folate carrier protein (RFC-1), folate transporter 1, placental folate transporter (FOLT), or intestinal folate carrier (IFC-1), is a multi-pass membrane protein primarily located in the liver and placenta, where SLC19A1 plays a crucial role in the transport of folate and derivatives into cells. SLC19A1 is essential for cellular folate uptake, which is vital for DNA synthesis and repair, as well as for the production of red blood cells. SLC19A1 undergoes heavy glycosylation, which is important for stability and function as a transporter. SLC19A1 mediates the uptake of methotrexate, an antifolate drug widely used in cancer therapy and as an immunosuppressive agent, by mimicking natural folates and inhibiting critical cellular biosynthetic pathways. This dual role in transporting both folate and methotrexate highlights SLC19A1′s significance in normal physiology and therapeutic contexts, making SLC19A1 (D-6) monoclonal antibody a valuable tool for researchers studying folate metabolism and drug interactions in mouse models.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SLC19A1 Antibody (D-6) References:
- Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. | Hou, Z. and Matherly, LH. 2014. Curr Top Membr. 73: 175-204. PMID: 24745983
- SLC19A1 Is an Importer of the Immunotransmitter cGAMP. | Ritchie, C., et al. 2019. Mol Cell. 75: 372-381.e5. PMID: 31126740
- SLC19A1 transports immunoreactive cyclic dinucleotides. | Luteijn, RD., et al. 2019. Nature. 573: 434-438. PMID: 31511694
- SLC19A1 May Serve as a Potential Biomarker for Diagnosis and Prognosis in Osteosarcoma. | Li, C., et al. 2020. Clin Lab. 66: PMID: 33180421
- Hypoxia-Immune-Related Gene SLC19A1 Serves as a Potential Biomarker for Prognosis in Multiple Myeloma. | Li, W., et al. 2022. Front Immunol. 13: 843369. PMID: 35958555
- Methotrexate recognition by the human reduced folate carrier SLC19A1. | Wright, NJ., et al. 2022. Nature. 609: 1056-1062. PMID: 36071163
- Recognition of cyclic dinucleotides and folates by human SLC19A1. | Zhang, Q., et al. 2022. Nature. 612: 170-176. PMID: 36265513
- Molecular mechanism of substrate recognition by folate transporter SLC19A1. | Dang, Y., et al. 2022. Cell Discov. 8: 141. PMID: 36575193
- Correlation between methylation level of the SLC19A1 promoter region and methotrexate metabolism in adult acute lymphoblastic leukemia. | Huang, X., et al. 2023. Pharmacogenomics. 24: 261-268. PMID: 36999405
- SLC19A1 Gene Polymorphism; Risk Factor for Preeclampsia. | Nasir, I., et al. 2025. J Coll Physicians Surg Pak. 35: 306-312. PMID: 40055164
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SLC19A1 Antibody (D-6) | sc-271276 | 200 µg/ml | $316.00 | |||
SLC19A1 Antibody (D-6): m-IgGκ BP-HRP Bundle | sc-521899 | 200 µg Ab, 40 µg BP | $354.00 | |||
SLC19A1 Antibody (D-6): m-IgG2b BP-HRP Bundle | sc-548982 | 200 µg Ab; 10 µg BP | $354.00 | |||
SLC19A1 Antibody (D-6) AC | sc-271276 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SLC19A1 Antibody (D-6) HRP | sc-271276 HRP | 200 µg/ml | $316.00 | |||
SLC19A1 Antibody (D-6) FITC | sc-271276 FITC | 200 µg/ml | $330.00 | |||
SLC19A1 Antibody (D-6) PE | sc-271276 PE | 200 µg/ml | $343.00 | |||
SLC19A1 Antibody (D-6) Alexa Fluor® 488 | sc-271276 AF488 | 200 µg/ml | $357.00 | |||
SLC19A1 Antibody (D-6) Alexa Fluor® 546 | sc-271276 AF546 | 200 µg/ml | $357.00 | |||
SLC19A1 Antibody (D-6) Alexa Fluor® 594 | sc-271276 AF594 | 200 µg/ml | $357.00 | |||
SLC19A1 Antibody (D-6) Alexa Fluor® 647 | sc-271276 AF647 | 200 µg/ml | $357.00 | |||
SLC19A1 Antibody (D-6) Alexa Fluor® 680 | sc-271276 AF680 | 200 µg/ml | $357.00 | |||
SLC19A1 Antibody (D-6) Alexa Fluor® 790 | sc-271276 AF790 | 200 µg/ml | $357.00 | |||
SLC19A1 (D-6) Neutralizing Peptide | sc-271276 P | 100 µg/0.5 ml | $68.00 |