Syntaxin 8 Antibody (48): sc-136092

Syntaxin 8 Antibody (48) is a mouse monoclonal IgG2a antibody that detects Syntaxin 8 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Syntaxin 8, also known as STX8 or CARB, is a 236 amino acid single-pass type IV membrane protein that plays a crucial role in the early secretory pathway, functioning as a vesicle trafficking protein that facilitates the transport of proteins from the cis-Golgi membrane to the endoplasmic reticulum (ER). Syntaxin 8 is highly expressed in various tissues, including the liver, brain, kidney, lung, placenta, spleen, pancreas, and skeletal muscle, highlighting its importance in cellular processes across different organ systems. Notably, Syntaxin 8 contains a t-SNARE coiled-coil homology domain and is involved in the formation of a SNARE complex with Syntaxin 7, v-SNARE Vti1p, and endobrevin, which is essential for the homotypic fusion of late endosomes. The proper functioning of Syntaxin 8 is vital for maintaining cellular homeostasis and ensuring efficient protein transport, making Syntaxin 8 a significant target for research in cellular biology and related fields. Anti-Syntaxin 8 antibody (48) provides a reliable tool for studying the dynamics of vesicle trafficking and the role of Syntaxin 8 in various physiological and pathological contexts.

The preferred Syntaxin 8 antibody is Syntaxin 8 Antibody (A-9): sc-376521.