ACAD-10 Antibody (F-11): sc-393248

ACAD-10 Antibody (F-11) is a mouse monoclonal IgM antibody that detects ACAD-10 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACAD-10 (F-11) antibody is available as the non-conjugated form. The Acyl-CoA dehydrogenase (ACAD) family of enzymes plays a crucial role in the catabolism of fatty acids and amino acids, providing essential energy sources for the heart and skeletal muscle. ACAD-10, also known as acyl-Coenzyme A dehydrogenase family member 10, consists of 1,059 amino acids and is expressed in four alternatively spliced isoforms, with the highest expression levels found in the liver, kidney, pancreas, and spleen. Notably, ACAD-10 is involved in the mitochondrial fatty acid oxidation pathway, which is vital for energy production, particularly during periods of fasting or prolonged exercise. The gene encoding ACAD-10 is located on chromosome 12, a region that encompasses over 1,100 genes and accounts for approximately 4.5% of the human genome. This chromosome is linked to various diseases, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome, and trisomy 12p, which can lead to facial developmental defects and seizure disorders. ACAD-10′s ability to interact with other proteins involved in metabolic pathways further underscores its importance in maintaining cellular energy homeostasis and overall metabolic health.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ACAD-10 Antibody (F-11) References:

1. Disease genes and chromosomes: disease maps of the human genome.Chromosome 12.  |  Gilbert, F. and Kauff, N. 2000. Genet Test. 4: 319-33. PMID: 11142767
2. A high-resolution map of human chromosome 12.  |  Montgomery, KT., et al. 2001. Nature. 409: 945-6. PMID: 11237017
3. Structures of isobutyryl-CoA dehydrogenase and enzyme-product complex: comparison with isovaleryl- and short-chain acyl-CoA dehydrogenases.  |  Battaile, KP., et al. 2004. J Biol Chem. 279: 16526-34. PMID: 14752098
4. Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1.  |  Ye, X., et al. 2004. Mol Biol Rep. 31: 191-5. PMID: 15560374
5. Acyl-CoA dehydrogenases: Dynamic history of protein family evolution.  |  Swigonová, Z., et al. 2009. J Mol Evol. 69: 176-93. PMID: 19639238
6. Cytogenetic and molecular analysis in trisomy 12p.  |  Allen, TL., et al. 1996. Am J Med Genet. 63: 250-6. PMID: 8723118
7. Isolated isobutyryl-CoA dehydrogenase deficiency: an unrecognized defect in human valine metabolism.  |  Roe, CR., et al. 1998. Mol Genet Metab. 65: 264-71. PMID: 9889013

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACAD-10 Antibody (F-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ACAD-10 Antibody (F-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACAD-10 Antibody (F-11) Specifications

Alternate Product Name: ACAD-10

Product Clone Name: F-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 409-439

Epitope Target: ACAD-10

Epitope Species: human

Product Reactivity/Detection: ACAD-10

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ACAD-10 Antibody (F-11): P: Blocking Peptide