p-ACCα Antibody (F-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects p-ACCα protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p-ACCα (F-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Acetyl-CoA carboxylase (ACC) plays a crucial role in lipid metabolism by catalyzing the conversion of acetyl-CoA to malonyl-CoA, which is the rate-limiting step in fatty acid synthesis. This process is vital for maintaining energy homeostasis and regulating fatty acid levels in cells. p-ACCα, specifically, is essential for the biogenesis of long-chain fatty acids, while ACCβ is involved in controlling mitochondrial fatty acid oxidation. p-ACCα activity is regulated through phosphorylation and dephosphorylation of specific serine residues, which toggle between active and inactive states, as well as through allosteric modulation by metabolites such as citrate and palmitoyl-CoA. ACCα is located on human chromosome 17 and is predominantly expressed in lipogenic tissues, highlighting significance in metabolic pathways. Understanding p-ACCα regulatory mechanisms is critical for elucidating roles in metabolic disorders and developing therapeutic strategies targeting lipid metabolism.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-ACCα Antibody (F-2) | sc-271965 | 200 µg/ml | $316.00 | |||
p-ACCα Antibody (F-2): m-IgG Fc BP-HRP Bundle | sc-527311 | 200 µg Ab; 10 µg BP | $354.00 | |||
p-ACCα Antibody (F-2): m-IgG1 BP-HRP Bundle | sc-532684 | 200 µg Ab; 20 µg BP | $354.00 | |||
p-ACCα Antibody (F-2) AC | sc-271965 AC | 500 µg/ml, 25% agarose | $416.00 | |||
p-ACCα Antibody (F-2) HRP | sc-271965 HRP | 200 µg/ml | $316.00 | |||
p-ACCα Antibody (F-2) FITC | sc-271965 FITC | 200 µg/ml | $330.00 | |||
p-ACCα Antibody (F-2) PE | sc-271965 PE | 200 µg/ml | $343.00 | |||
p-ACCα Antibody (F-2) Alexa Fluor® 488 | sc-271965 AF488 | 200 µg/ml | $357.00 | |||
p-ACCα Antibody (F-2) Alexa Fluor® 546 | sc-271965 AF546 | 200 µg/ml | $357.00 | |||
p-ACCα Antibody (F-2) Alexa Fluor® 594 | sc-271965 AF594 | 200 µg/ml | $357.00 | |||
p-ACCα Antibody (F-2) Alexa Fluor® 647 | sc-271965 AF647 | 200 µg/ml | $357.00 | |||
p-ACCα Antibody (F-2) Alexa Fluor® 680 | sc-271965 AF680 | 200 µg/ml | $357.00 | |||
p-ACCα Antibody (F-2) Alexa Fluor® 790 | sc-271965 AF790 | 200 µg/ml | $357.00 | |||
p-ACCα (F-2) Neutralizing Peptide | sc-271965 P | 100 µg/0.5 ml | $68.00 |