ACE Antibody (2Q2296): sc-69994
- ACE Antibody (2Q2296) is a mouse monoclonal IgG1 provided at 500 µl supernatant
- recommended for detection of C-terminal domain of denatured ACE of mouse, rat, human, bovine, feline and canine origin by WB, IF and IHC(P)
- See ACE (2E2): sc-23908 for ACE antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ACE Antibody (2Q2296). This work is in progress.
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ACE Antibody (2Q2296) is a mouse monoclonal IgG1 antibody designed to detect angiotensin-converting enzyme (ACE), also known as CD143 or Angiotensin Converting Enzyme 1. Anti-ACE antibody (2Q2296) targets the C-terminal domain of denatured ACE and effectively recognizes ACE proteins from mouse, rat, human, bovine, feline, and canine origins through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Available in a non-conjugated form, ACE monoclonal antibody (2Q2296) offers flexibility for various research protocols. Angiotensin-converting enzyme (ACE) is a crucial carboxy-terminal dipeptidyl exo-peptidase involved in the renin-angiotensin system, where ACE catalyzes the conversion of Angiotensin I to the potent vasopressor hormone Angiotensin II, playing a key role in regulating blood pressure and maintaining electrolyte balance. Additionally, ACE is responsible for inactivating bradykinin, a vasodepressor peptide, which is essential for fluid and electrolyte homeostasis. ACE exists in two main isoforms: pulmonary ACE (ACEP), a glycoprotein expressed in vascular endothelial cells of organs such as the lung, liver, adrenal cortex, pancreas, kidney, and spleen, and testicular ACE (ACET), which is exclusively expressed in adult testis by developing sperm cells, specifically late pachytene spermatocytes. Proper functioning of ACE is vital for cardiovascular health, and dysregulation of ACE activity is associated with hypertension and other cardiovascular disorders, making ACE (2Q2296) monoclonal antibody an indispensable tool for researchers studying these conditions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACE Antibody (2Q2296) | sc-69994 | 500 µl supernatant | $316.00 |