AKR7A2 Antibody (Y02): sc-100503
- AKR7A2 Antibody (Y02) is a mouse monoclonal IgG1 κ AKR7A2 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant AKR7A2 of human origin
- recommended for detection of AKR7A2 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AKR7A2 Antibody (Y02). This work is in progress.
AKR7A2 Antibody (Y02) is a mouse monoclonal IgG1 kappa light chain antibody that detects the AKR7A2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-AKR7A2 antibody (Y02) is available as a non-conjugated format. The aldo-keto reductase 7 (AKR7) family, which includes AKR7A2, AKR7A3, and AKR7A4 in humans, plays a crucial role in the metabolism of Aflatoxin B1 and other dicarbonyl-containing compounds. Notably, AKR7A2 is predominantly expressed in the liver, where AKR7A2 is involved in the detoxification of harmful substances, including environmental carcinogens like aflatoxin. AKR7A2′s ability to metabolize compounds with ketone groups on adjacent carbon atoms is vital for maintaining cellular health and preventing the accumulation of toxic metabolites. Furthermore, the human AKR7A2 gene is located in a chromosomal region frequently deleted in sporadic colorectal cancer, highlighting AKR7A2′s potential role as a tumor suppressor. AKR7A2′s constitutive expression in the liver serves as an endogenous chemo-preventative mechanism, thereby underscoring AKR7A2′s importance in cancer prevention and metabolic regulation.
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AKR7A2 Antibody (Y02) References:
- Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues. | Kelly, VP., et al. 2000. Biochem J. 348 Pt 2: 389-400. PMID: 10816434
- Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins. | Kelly, VP., et al. 2002. Biochem J. 366: 847-61. PMID: 12071861
- A novel aldo-keto reductase from Escherichia coli can increase resistance to methylglyoxal toxicity. | Grant, AW., et al. 2003. FEMS Microbiol Lett. 218: 93-9. PMID: 12583903
- The high resolution crystal structure of rat liver AKR7A1: understanding the substrate specificites of the AKR7 family. | Kozma, E., et al. 2003. Chem Biol Interact. 143-144: 289-97. PMID: 12604215
- The aldo-keto reductase superfamily homepage. | Hyndman, D., et al. 2003. Chem Biol Interact. 143-144: 621-31. PMID: 12604248
- Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells. | Praml, C., et al. 2003. Oncogene. 22: 4765-73. PMID: 12879023
- Detoxication of the environmental pollutant acrolein by a rat liver aldo-keto reductase. | Gardner, R., et al. 2004. Toxicol Lett. 148: 65-72. PMID: 15019089
- Substrate specificity of an aflatoxin-metabolizing aldehyde reductase. | Ellis, EM. and Hayes, JD. 1995. Biochem J. 312 (Pt 2): 535-41. PMID: 8526867
- Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase. | Ireland, LS., et al. 1998. Biochem J. 332 (Pt 1): 21-34. PMID: 9576847
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AKR7A2 Antibody (Y02) | sc-100503 | 100 µg/ml | $333.00 |