Carbonyl reductase 1 Antibody (Z-8): sc-100518
- Carbonyl reductase 1 Antibody (Z-8) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against recombinant Carbonyl reductase 1 of human origin
- recommended for detection of Carbonyl reductase 1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Carbonyl reductase 1 Antibody (Z-8). This work is in progress.
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Carbonyl reductase 1 Antibody (Z-8) is a mouse monoclonal IgG1 antibody that detects Carbonyl reductase 1 (CBR1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). CBR1 is a crucial enzyme involved in the metabolism of various carbonyl compounds, particularly those generated from lipid peroxidation, converting them into corresponding alcohols through an NADPH-dependent reduction process. CBR1 monoclonal antibody (Z-8) recognizes a protein predominantly located in the cytoplasm, where CBR1 plays a key role in detoxifying harmful metabolites and regulating bioactive lipid levels. Understanding CBR1′s cellular localization highlights its involvement in metabolic pathways and potential impact on drug metabolism and pharmacokinetics. Genetic variations in CBR1 can lead to differences in metabolic efficiency among individuals, influencing responses to medications and susceptibility to metabolic disorders. Anti-CBR1 antibody (Z-8) serves as an essential tool for researchers studying the metabolic functions of this enzyme and its implications in health and disease.
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Carbonyl reductase 1 Antibody (Z-8) References:
- Neuroprotective effects of PEP-1-carbonyl reductase 1 against oxidative-stress-induced ischemic neuronal cell damage. | Kim, YN., et al. 2014. Free Radic Biol Med. 69: 181-96. PMID: 24440593
- The modulation of carbonyl reductase 1 by polyphenols. | Boušová, I., et al. 2015. Drug Metab Rev. 47: 520-33. PMID: 26415702
- Kinetic features of carbonyl reductase 1 acting on glutathionylated aldehydes. | Moschini, R., et al. 2017. Chem Biol Interact. 276: 127-132. PMID: 28274719
- Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs. | Hara, A., et al. 2017. Biochem Pharmacol. 138: 185-192. PMID: 28450226
- The role of carbonyl reductase 1 in drug discovery and development. | Shi, SM. and Di, L. 2017. Expert Opin Drug Metab Toxicol. 13: 859-870. PMID: 28712324
- Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate. | Ramsden, D., et al. 2018. Drug Metab Dispos. 46: 1434-1440. PMID: 30068520
- Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta. | Khazeem, MM., et al. 2020. FEBS Lett. 594: 3395-3405. PMID: 32767399
- Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice. | Bell, RMB., et al. 2021. Mol Metab. 48: 101225. PMID: 33785425
- Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation. | Mao, L., et al. 2021. Transl Stroke Res. 12: 711-724. PMID: 33964000
- Development of transgenic mice overexpressing mouse carbonyl reductase 1. | Yokoyama, M., et al. 2023. Mol Biol Rep. 50: 531-540. PMID: 36352178
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Carbonyl reductase 1 Antibody (Z-8) | sc-100518 | 100 µg/ml | $333.00 |