cathepsin E Antibody (C-7): sc-166501
- cathepsin E Antibody (C-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 57-75 near the N-terminus of cathepsin E of human origin
- recommended for detection of cathepsin E of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for cathepsin E Antibody (C-7) for WB and IHC(P) applications. These reagents are now offered in bundles with cathepsin E Antibody (C-7) (see ordering information below).
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Cathepsin E Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects cathepsin E in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Cathepsin E is a nonlysosomal, intracellular proteinase that plays a crucial role in processing proteins and peptides, which is essential for maintaining cellular homeostasis and regulating immune responses. Unique localization within the cytoplasm allows cathepsin E to participate in the degradation of misfolded or damaged proteins, thereby preventing the accumulation of potentially harmful aggregates. Cathepsin E is involved in the maturation of certain immune cells, highlighting its importance in both innate and adaptive immunity. The ability of cathepsin E to interact with specific proteins, such as major histocompatibility complex (MHC) class II molecules, further underscores its significance in antigen presentation and immune system function. Anti-cathepsin E antibody (C-7) serves as an invaluable tool for researchers studying proteolytic pathways and immune responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cathepsin E Antibody (C-7) References:
- Association of cathepsin E deficiency with development of atopic dermatitis. | Tsukuba, T., et al. 2003. J Biochem. 134: 893-902. PMID: 14769879
- Modeling the tertiary structure of human cathepsin-E. | Chou, KC. 2005. Biochem Biophys Res Commun. 331: 56-60. PMID: 15845357
- Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors. | Tsukuba, T., et al. 2006. J Biochem. 140: 57-66. PMID: 16877769
- Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E. | Kakehashi, H., et al. 2007. J Immunol. 179: 5728-37. PMID: 17947645
- Molecular imaging of Cathepsin E-positive tumors in mice using a novel protease-activatable fluorescent probe. | Abd-Elgaliel, WR., et al. 2011. Mol Biosyst. 7: 3207-3213. PMID: 21935563
- Pancreatic cancer-associated Cathepsin E as a drug activator. | Abd-Elgaliel, WR., et al. 2013. J Control Release. 167: 221-7. PMID: 23422726
- High Expression of Cathepsin E in Tissues but Not Blood of Patients with Barrett's Esophagus and Adenocarcinoma. | Fisher, OM., et al. 2015. Ann Surg Oncol. 22: 2431-8. PMID: 25348778
- Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin. | Harada, Y., et al. 2017. Cell Mol Neurobiol. 37: 437-443. PMID: 27116544
- An Enzyme-Activatable Aggregation-Induced-Emission Probe: Intraoperative Pathological Fluorescent Diagnosis of Pancreatic Cancer via Specific Cathepsin E. | Zhu, Z., et al. 2022. Adv Mater. 34: e2107444. PMID: 34693566
- An immunohistochemical study of cathepsin E in Alzheimer-type dementia brains. | Bernstein, HG. and Wiederanders, B. 1994. Brain Res. 667: 287-90. PMID: 7697369
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cathepsin E Antibody (C-7) | sc-166501 | 200 µg/ml | $316.00 | |||
cathepsin E Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-540112 | 200 µg Ab; 10 µg BP | $354.00 | |||
cathepsin E Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-541910 | 200 µg Ab; 20 µg BP | $354.00 | |||
cathepsin E (C-7) Neutralizing Peptide | sc-166501 P | 100 µg/0.5 ml | $68.00 |