cathepsin E Antibody (C-11): sc-166286
- cathepsin E Antibody (C-11) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 141-180 mapping within an internal region of cathepsin E of human origin
- recommended for detection of cathepsin E of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cathepsin E Antibody (C-11) for WB and IHC(P) applications. These reagents are now offered in bundles with cathepsin E Antibody (C-11) (see ordering information below).
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Cathepsin E Antibody (C-11) is a mouse monoclonal IgG2b antibody that detects cathepsin E in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Cathepsin E is a nonlysosomal, intracellular proteinase that plays a crucial role in the immune response by processing antigens and regulating inflammation. Anti-cathepsin E antibody (C-11) recognizes specific peptide bonds essential for generating antigenic peptides presented by major histocompatibility complex (MHC) molecules, thereby influencing T cell activation and overall adaptive immune response. Proper functioning of cathepsin E is vital for maintaining immune homeostasis, and dysregulation of cathepsin E activity has been implicated in various diseases, including autoimmune disorders and cancer. Cathepsin E (C-11) antibody serves as an invaluable tool for researchers studying this important protease in cellular processes and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cathepsin E Antibody (C-11) References:
- Cathepsin E and subtypes of intestinal metaplasia in carcinogenesis of the human stomach. | Lin, CK., et al. 2001. Zhonghua Yi Xue Za Zhi (Taipei). 64: 331-6. PMID: 11534800
- The expression and function of cathepsin E in dendritic cells. | Chain, BM., et al. 2005. J Immunol. 174: 1791-800. PMID: 15699105
- Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. | Kawakubo, T., et al. 2007. Cancer Res. 67: 10869-78. PMID: 18006832
- Cathepsin E induces itch-related response through the production of endothelin-1 in mice. | Andoh, T., et al. 2012. Eur J Pharmacol. 686: 16-21. PMID: 22546226
- Cathepsin E generates a sumoylated intracellular fragment of the cell adhesion molecule L1 to promote neuronal and Schwann cell migration as well as myelination. | Lutz, D., et al. 2014. J Neurochem. 128: 713-24. PMID: 24118054
- Expression, purification and auto-activation of cathepsin E from insect cells. | Železnik, TZ., et al. 2015. Protein Pept Lett. 22: 525-31. PMID: 25962065
- High Expression of Cathepsin E is Associated with the Severity of Airflow Limitation in Patients with COPD. | Cao, WJ., et al. 2016. COPD. 13: 160-6. PMID: 26488201
- Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis. | Harada, Y., et al. 2019. Pain. 160: 2050-2062. PMID: 31095099
- miR-185-5p Represses Cells Growth and Metastasis of Osteosarcoma via Targeting Cathepsin E. | Wu, Y., et al. 2022. Int J Toxicol. 41: 115-125. PMID: 35213250
- Cathepsin E expression by normal and premalignant cervical epithelium. | Mota, F., et al. 1997. Am J Pathol. 150: 1223-9. PMID: 9094979
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cathepsin E Antibody (C-11) | sc-166286 | 200 µg/ml | $316.00 | |||
cathepsin E Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-534747 | 200 µg Ab; 40 µg BP | $354.00 | |||
cathepsin E Antibody (C-11): m-IgG2b BP-HRP Bundle | sc-549293 | 200 µg Ab; 10 µg BP | $354.00 |