LCAT Antibody (D-2): sc-376682
- LCAT Antibody (D-2) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 283-423 mapping near the C-terminus of LCAT of human origin
- LCAT Antibody (D-2) is recommended for detection of precursor and mature LCAT of human origin by WB, IP, IF and ELISA
- Anti-LCAT Antibody (D-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of LCAT (D-2): sc-376682.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LCAT Antibody (D-2) for WB applications. These reagents are now offered in bundles with LCAT Antibody (D-2) (see ordering information below).
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SEE ALSO...
LCAT Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects lecithin-cholesterol acyltransferase (LCAT) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LCAT antibody (D-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LCAT plays a vital role in lipid metabolism by catalyzing the esterification of cholesterol, which is essential for the formation of high-density lipoprotein (HDL) and the transport of cholesterol in the bloodstream. This process is crucial for maintaining cellular cholesterol homeostasis and preventing the accumulation of excess cholesterol, which can lead to atherosclerosis and cardiovascular diseases. LCAT deficiency is associated with fish-eye disease, a rare genetic disorder characterized by abnormal HDL metabolism, highlighting the importance of LCAT in lipid transport and overall cardiovascular health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LCAT Antibody (D-2) References:
- Classical LCAT deficiency resulting from a novel homozygous dinucleotide deletion in exon 4 of the human lecithin: cholesterol acyltransferase gene causing a frameshift and stop codon at residue 144. | Teh, EM., et al. 1999. Atherosclerosis. 146: 141-51. PMID: 10487497
- T13M mutation of lecithin-cholesterol acyltransferase gene causes fish-eye disease. | Miida, T., et al. 2004. Clin Chim Acta. 343: 201-8. PMID: 15115696
- Molecular mechanism of reverse cholesterol transport: reaction of pre-beta-migrating high-density lipoprotein with plasma lecithin/cholesterol acyltransferase. | Nakamura, Y., et al. 2004. Biochemistry. 43: 14811-20. PMID: 15544352
- Contribution of cholesteryl ester transfer protein and lecithin:cholesterol acyltransferase to HDL size distribution. | Huesca-Gómez, C., et al. 2004. Endocr Res. 30: 403-15. PMID: 15554357
- Familial LCAT deficiency and fish-eye disease. | McIntyre, N. 1988. J Inherit Metab Dis. 11 Suppl 1: 45-56. PMID: 3141686
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LCAT Antibody (D-2) | sc-376682 | 200 µg/ml | $316.00 | |||
LCAT Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-529920 | 200 µg Ab; 10 µg BP | $354.00 | |||
LCAT Antibody (D-2): m-IgGκ BP-HRP Bundle | sc-523043 | 200 µg Ab, 40 µg BP | $354.00 | |||
LCAT Antibody (D-2): m-IgG1 BP-HRP Bundle | sc-543765 | 200 µg Ab; 20 µg BP | $354.00 | |||
LCAT Antibody (D-2) AC | sc-376682 AC | 500 µg/ml, 25% agarose | $416.00 | |||
LCAT Antibody (D-2) HRP | sc-376682 HRP | 200 µg/ml | $316.00 | |||
LCAT Antibody (D-2) FITC | sc-376682 FITC | 200 µg/ml | $330.00 | |||
LCAT Antibody (D-2) PE | sc-376682 PE | 200 µg/ml | $343.00 | |||
LCAT Antibody (D-2) Alexa Fluor® 488 | sc-376682 AF488 | 200 µg/ml | $357.00 | |||
LCAT Antibody (D-2) Alexa Fluor® 546 | sc-376682 AF546 | 200 µg/ml | $357.00 | |||
LCAT Antibody (D-2) Alexa Fluor® 594 | sc-376682 AF594 | 200 µg/ml | $357.00 | |||
LCAT Antibody (D-2) Alexa Fluor® 647 | sc-376682 AF647 | 200 µg/ml | $357.00 | |||
LCAT Antibody (D-2) Alexa Fluor® 680 | sc-376682 AF680 | 200 µg/ml | $357.00 | |||
LCAT Antibody (D-2) Alexa Fluor® 790 | sc-376682 AF790 | 200 µg/ml | $357.00 |