MMP-1 Antibody (SB12e): sc-58377

MMP-1 Antibody (SB12e) is a mouse monoclonal IgG2b antibody engineered to detect the human matrix metalloproteinase-1 (MMP-1) protein, also known as interstitial collagenase, fibroblast collagenase, or collagenase-1. MMP-1 monoclonal antibody (SB12e) targets the full-length human MMP-1 protein, ensuring precise binding and reliable detection in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MMP-1 is predominantly located in the extracellular matrix, where MMP-1 plays a crucial role in the degradation of key extracellular components such as collagen, gelatin, fibronectin, laminin, and proteoglycans. This localization is essential for processes like tissue remodeling, wound healing, and angiogenesis, as MMP-1 facilitates cellular migration and invasion necessary for these physiological functions. MMP-1 activity is tightly regulated by cellular signaling pathways, including downregulation by the tumor suppressor protein p53, which is vital for maintaining cellular homeostasis and preventing excessive tissue degradation. MMP-1 requires calcium and zinc ions for enzymatic activity, a characteristic feature of the matrix metalloproteinase family. Additionally, MMP-1 interacts with other metalloproteinases such as MMP-9 (gelatinase B) to degrade bone collagens, contributing to osteoclastic bone resorption and playing a role in pathological conditions like rheumatoid arthritis. Available in a non-conjugated form, MMP-1 (SB12e) antibody is ideal for research in fields such as oncology, arthritis, and tissue engineering, providing reliable performance and specificity to support your scientific endeavors.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MMP-1 Antibody (SB12e) has 26 citations in a variety of scientific publications.

Primary antibodies like Anti-MMP-1 Antibody (SB12e) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MMP-1 Antibody (SB12e) Specifications

Alternate Product Name: MMP-1

Product Clone Name: SB12e

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: MMP-1

Epitope Species: human

Product Reactivity/Detection: MMP-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 26 citations in various scientific publications

Available Conjugates/Forms for MMP-1 Antibody (SB12e): N/A

The preferred MMP-1 antibody is MMP-1 Antibody (3B6): sc-21731.