ODC Antibody (G-10): sc-390366
- ODC Antibody (G-10) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 351-385 within an internal region of ODC of human origin
- recommended for detection of ODC of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ODC Antibody (G-10) for WB and IHC(P) applications. These reagents are now offered in bundles with ODC Antibody (G-10) (see ordering information below).
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ODC Antibody (G-10) is a mouse monoclonal IgG1 antibody that detects ornithine decarboxylase (ODC) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ODC is a crucial enzyme that catalyzes the conversion of ornithine to putrescine, marking the first step in polyamine biosynthesis, which is vital for numerous cellular processes such as growth, differentiation, and apoptosis. The regulation of ODC is particularly important due to involvement in cancer development; overexpression of ODC is linked to increased cell proliferation and tumorigenesis. Notably, ODC is subject to intricate regulatory mechanisms, including feedback inhibition by elevated polyamine levels that enhance the translation of antizyme mRNA, leading to degradation through the 26S proteasome. Additionally, ODC′s role in angiogenesis is underscored by association with the suppression of endostatin expression, which is critical for endothelial cell proliferation. The ODC gene is located on human chromosome 2p25, highlighting significance in both normal physiology and pathological conditions. Anti-ODC antibody (G-10) is an essential tool for researchers investigating the multifaceted roles of ODC in cellular processes and disease states.
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ODC Antibody (G-10) References:
- Secretion of soluble complement inhibitors factor H and factor H-like protein (FHL-1) by ovarian tumour cells. | Junnikkala, S., et al. 2002. Br J Cancer. 87: 1119-27. PMID: 12402151
- Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells. | Kang, YH., et al. 2012. Immunobiology. 217: 455-64. PMID: 22088229
- Cloning, expression and purification of the factor H binding protein and its interaction with factor H. | Yarian, F., et al. 2016. Iran J Microbiol. 8: 29-35. PMID: 27092222
- Interaction of uromodulin and complement factor H enhances C3b inactivation. | Liu, M., et al. 2016. J Cell Mol Med. 20: 1821-8. PMID: 27113631
- Loss of Complement Factor H in Plasma Increases Endothelial Cell Migration. | Liu, J. and Hoh, J. 2017. J Cancer. 8: 2184-2190. PMID: 28819420
- Increased plasma complement factor H is associated with geriatric depression. | Shin, C., et al. 2019. Int Psychogeriatr. 31: 101-108. PMID: 29798743
- Absence of complement factor H reduces physical performance in C57BL6 mice. | Seldeen, KL., et al. 2020. Immunobiology. 225: 152003. PMID: 32962822
- Local complement factor H protects kidney endothelial cell structure and function. | Mahajan, S., et al. 2021. Kidney Int. 100: 824-836. PMID: 34139209
- The role of complement factor H in gestational diabetes mellitus and pregnancy. | Li, J., et al. 2021. BMC Pregnancy Childbirth. 21: 562. PMID: 34404360
- Characterization of the lymphocyte membrane receptor for factor H (beta 1H-globulin) with an antibody to anti-factor H idiotype. | Lambris, JD. and Ross, GD. 1982. J Exp Med. 155: 1400-11. PMID: 6461713
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ODC Antibody (G-10) | sc-390366 | 200 µg/ml | $316.00 | |||
ODC Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-538082 | 200 µg Ab; 10 µg BP | $354.00 | |||
ODC Antibody (G-10): m-IgGκ BP-HRP Bundle | sc-535617 | 200 µg Ab; 40 µg BP | $354.00 | |||
ODC Antibody (G-10): m-IgG1 BP-HRP Bundle | sc-545513 | 200 µg Ab; 20 µg BP | $354.00 | |||
ODC (G-10) Neutralizing Peptide | sc-390366 P | 100 µg/0.5 ml | $68.00 |