PLC β4 Antibody (A-8): sc-166131

PLC β4 Antibody (A-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects PLC beta 4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PLC β4 (A-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PLC beta 4 protein is a member of the phosphoinositide-specific phospholipase C family, which is crucial for initiating receptor-mediated signal transduction. PLC beta 4 protein catalyzes the hydrolysis of phosphatidylinositol 4, 5-bisphosphate to produce inositol 1, 4, 5-triphosphate and diacylglycerol, two important second messengers that play significant roles in various cellular processes, including cell growth, differentiation, and apoptosis. Proper functioning of PLC beta 4 is vital for maintaining cellular signaling pathways, and dysregulation has been implicated in several diseases, including cancer and cardiovascular disorders. Understanding PLC beta 4 interactions and regulatory mechanisms can provide insights into therapeutic targets for these conditions, making anti-PLC β4 antibody (A-8) an essential tool for researchers studying signal transduction and related pathways.

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PLC β4 Antibody (A-8) References:

1. Role of thalamic phospholipase C[beta]4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain.  |  Miyata, M., et al. 2003. J Neurosci. 23: 8098-108. PMID: 12954872
2. Regulation of inositol phospholipid-specific phospholipase C isozymes.  |  Rhee, SG. and Choi, KD. 1992. J Biol Chem. 267: 12393-6. PMID: 1319994
3. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.  |  Koch, CA., et al. 1991. Science. 252: 668-74. PMID: 1708916
4. A second gene product of the inositol-phospholipid-specific phospholipase C delta subclass.  |  Meldrum, E., et al. 1991. Eur J Biochem. 196: 159-65. PMID: 1848183
5. A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity.  |  Emori, Y., et al. 1989. J Biol Chem. 264: 21885-90. PMID: 2557343
6. Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.  |  Suh, PG., et al. 1988. Proc Natl Acad Sci U S A. 85: 5419-23. PMID: 2840660
7. In silico analysis to identify miR-1271-5p/PLCB4 (phospholipase C Beta 4) axis mediated oxaliplatin resistance in metastatic colorectal cancer.  |  Lee, CC., et al. 2023. Sci Rep. 13: 4366. PMID: 36927770
8. A polypeptide derived from pilose antler ameliorates CUMS-induced depression-like behavior by SENP2-PLCβ4 signaling axis.  |  Dong, Y., et al. 2024. Eur J Pharmacol. 963: 176247. PMID: 38056617
9. Cloning of cDNA encoding rat phospholipase C-beta 4, a new member of the phospholipase C.  |  Kim, MJ., et al. 1993. Biochem Biophys Res Commun. 194: 706-12. PMID: 7688223
10. Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.  |  Wu, D., et al. 1993. Proc Natl Acad Sci U S A. 90: 5297-301. PMID: 8389480
11. Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3.  |  Jhon, DY., et al. 1993. J Biol Chem. 268: 6654-61. PMID: 8454637
12. cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4).  |  Alvarez, RA., et al. 1995. Genomics. 29: 53-61. PMID: 8530101

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PLC β4 Antibody (A-8) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-PLC β4 Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PLC β4 Antibody (A-8) Specifications

Alternate Product Name: PLC β4

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 876-1115

Epitope Target: PLC β4

Epitope Species: human

Product Reactivity/Detection: PLC β4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for PLC β4 Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin