Squalene synthetase Antibody (B-8): sc-365101

Squalene synthetase Antibody (B-8) is a mouse monoclonal IgG1 antibody that detects Squalene synthetase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Squalene synthetase plays a crucial role in cholesterol biosynthesis by catalyzing the conversion of transfarnesyl-diphosphate to squalene, marking the first specific step in the cholesterol biosynthetic pathway. This enzyme is strategically located at a branch point in the mevalonate pathway, which is essential for the production of isoprenoids, a class of compounds that are vital for various cellular functions, including membrane integrity and signaling. The importance of Squalene synthetase extends beyond enzymatic activity; anti-Squalene synthetase antibody (B-8) has shown interaction with Squalene epoxidase, another key enzyme in sterol biosynthesis, potentially forming a complex that regulates the rate of cholesterol production. Using Squalene synthetase (B-8) monoclonal antibody enables researchers to gain insights into the dynamics of cholesterol metabolism and its implications in health and disease.

The preferred Squalene synthetase antibody is Squalene synthetase Antibody (A-7): sc-271602.