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Squalene synthetase Antibody (B-8): sc-365101

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Datasheets
  • Squalene synthetase Antibody (B-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 335-359 near the C-terminus of Squalene synthetase of human origin
  • recommended for detection of Squalene synthetase of mouse, rat and human origin by WB, IP, IF and ELISA
  • m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Squalene synthetase Antibody (B-8) for WB applications. These reagents are now offered in bundles with Squalene synthetase Antibody (B-8) (see ordering information below).

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    Squalene synthetase Antibody (B-8) is a mouse monoclonal IgG1 antibody that detects Squalene synthetase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Squalene synthetase plays a crucial role in cholesterol biosynthesis by catalyzing the conversion of transfarnesyl-diphosphate to squalene, marking the first specific step in the cholesterol biosynthetic pathway. This enzyme is strategically located at a branch point in the mevalonate pathway, which is essential for the production of isoprenoids, a class of compounds that are vital for various cellular functions, including membrane integrity and signaling. The importance of Squalene synthetase extends beyond enzymatic activity; anti-Squalene synthetase antibody (B-8) has shown interaction with Squalene epoxidase, another key enzyme in sterol biosynthesis, potentially forming a complex that regulates the rate of cholesterol production. Using Squalene synthetase (B-8) monoclonal antibody enables researchers to gain insights into the dynamics of cholesterol metabolism and its implications in health and disease.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    Squalene synthetase Antibody (B-8)

    sc-365101
    200 µg/ml
    $316.00

    Squalene synthetase Antibody (B-8): m-IgG Fc BP-HRP Bundle

    sc-540311
    200 µg Ab; 10 µg BP
    $354.00

    Squalene synthetase Antibody (B-8): m-IgG1 BP-HRP Bundle

    sc-542032
    200 µg Ab; 20 µg BP
    $354.00

    Squalene synthetase (B-8) Neutralizing Peptide

    sc-365101 P
    100 µg/0.5 ml
    $68.00

    What application is the blocking peptide sc-365101 P appropriate for?

    Asked by: Randy McDonald
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-24
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    Rated 5 out of 5 by from Great immunofluorescence cytoplasmic stainingGreat immunofluorescence cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
    Date published: 2015-04-29
    Rated 5 out of 5 by from Good Western Blot data of Squalene synthetaseGood Western Blot data of Squalene synthetase expression in non-transfected and human Squalene synthetase transfected 293T whole cell lysates. -SCBT QC
    Date published: 2014-05-07
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    Squalene synthetase Antibody (B-8) is rated 5.0 out of 5 by 2.
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