TAT Antibody (D-9): sc-365512

TAT Antibody (D-9) is a mouse monoclonal IgG1 antibody that detects TAT (tyrosine aminotransferase) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TAT is a 454 amino acid protein that plays a crucial role in the mitochondria, where TAT functions as a homodimer and utilizes pyridoxal phosphate as a cofactor to catalyze the conversion of L-tyrosine into p-hydroxyphenylpyruvate, a key step in amino acid degradation. This enzymatic activity is vital for maintaining amino acid homeostasis and preventing the accumulation of toxic metabolites. Defects in the gene encoding TAT can lead to tyrosinemia type 2 (TYRO2), a metabolic disorder characterized by elevated levels of tyrosine in the blood and urine, which can result in serious health issues such as palmoplantar keratosis, painful corneal ulcers, and cognitive impairments. The gene encoding TAT is located on human chromosome 16, a region that encompasses over 900 genes and represents nearly 3% of the human genome, highlighting TAT′s importance in both metabolic processes and genetic regulation. Anti-TAT antibody (D-9) serves as an essential tool for researchers studying TAT′s implications in metabolic disorders and potential interactions with other proteins involved in amino acid metabolism.

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TAT Antibody (D-9) References:

1. Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes.  |  Blind, RD. and Garabedian, MJ. 2008. J Steroid Biochem Mol Biol. 109: 150-7. PMID: 18304804
2. Insulin-mediated regulation of tyrosine aminotransferase in rat hepatoma cells: inhibition of transcription and inhibition of enzyme degradation.  |  Moore, PS. and Koontz, JW. 1989. Arch Biochem Biophys. 275: 486-95. PMID: 2574563
3. Transcriptional and posttranscriptional regulation of tyrosine aminotransferase by insulin in rat hepatoma cells.  |  Crettaz, M., et al. 1988. Biochemistry. 27: 495-500. PMID: 2894848
4. Superinduction of tyrosine aminotransferase by actinomycin D in rat hepatoma (HTC) cells.  |  Thompson, EB., et al. 1970. J Mol Biol. 54: 159-75. PMID: 4395444
5. Stimulation of tyrosine aminotransferase synthesis by dexamethasone phosphate in cell culture.  |  Granner, DK., et al. 1968. J Mol Biol. 35: 291-301. PMID: 4398833
6. Expression of aryl hydrocarbon hydroxylase induction and suppression of tyrosine aminotransferase induction in somatic-cell hybrids.  |  Benedict, WF., et al. 1972. Proc Natl Acad Sci U S A. 69: 2179-83. PMID: 4403306
7. Mechanism of hormonal induction of tyrosine aminotransferase studied by measurement of the concentration of growing enzyme molecules.  |  Scott, WA., et al. 1972. Proc Natl Acad Sci U S A. 69: 2937-41. PMID: 4404146
8. Positive and negative cAMP-mediated control of tyrosine aminotransferase synthesis in Reuber H35 hepatoma cells.  |  Snoek, GT., et al. 1982. Eur J Biochem. 123: 217-22. PMID: 6121706
9. Concanavalin A alters the turnover rate of tyrosine aminotransferase in cultured hepatoma cells.  |  Donohue, TM., et al. 1982. Biochim Biophys Acta. 721: 94-100. PMID: 6127118
10. Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene.  |  Rennie, PS., et al. 1993. Mol Endocrinol. 7: 23-36. PMID: 8446105

The preferred TAT antibody is TAT Antibody (H-9): sc-376292.