UDP-GlcDH Antibody (B-1): sc-137057

UDP-GlcDH Antibody (B-1) is a mouse monoclonal IgG2a antibody that detects UDP-GlcDH in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). UDP-GlcDH, also known as UDP-glucose 6-dehydrogenase, plays a vital role in converting UDP-glucose to UDP-glucuronic acid, a key precursor in glycosaminoglycan biosynthesis including hyaluronan, heparan sulfate, and chondroitin sulfate. These glycosaminoglycans are essential components of the extracellular matrix, contributing significantly to signal transduction, cell migration, and cancer progression. UDP-GlcDH functions critically in the liver, where UDP-glucuronic acid enables detoxification and excretion of harmful compounds. Structurally, UDP-GlcDH exists as a homohexamer, a configuration highly conserved across species, showing 97% sequence identity among mammals. This structural integrity remains essential for enzymatic function and stability. Research has shown that TGFβ upregulates UDP-GlcDH expression, while hypoxia leads to downregulation, highlighting UDP-GlcDH′s role in cellular responses to environmental changes.

The preferred UDP-GlcDH antibody is UDP-GlcDH Antibody (B-4): sc-137058.