UGP2 Antibody (B-3): sc-377089

UGP2 Antibody (B-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects UGP2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-UGP2 antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. UGP2, also known as UDP-glucose pyrophosphorylase 2, UDPG, UGPP2, UDPGP2, or pHC379, is an evolutionarily conserved protein that belongs to the UDPGP type 1 family. UGP2 is primarily located in the cytoplasm, where UGP2 forms homooligomers and plays a crucial role in cellular metabolic pathways. UGP2 catalyzes the transfer of a glucose moiety from glucose-1-phosphate to UTP, resulting in the production of diphosphate and UDP-glucose. UDP-glucose serves as an essential precursor for polysaccharide synthesis. In the liver and muscle, UDP-glucose is a key precursor for glycogen synthesis, while in the liver, UDP-glucose also contributes to UDP-glucuronate formation. In the lactating mammary gland, UDP-glucose is converted to UDP-galactose, which is subsequently utilized in lactose production. UGP2′s ability to facilitate these critical metabolic processes underscores UGP2′s importance in energy storage and carbohydrate metabolism, making UGP2 (B-3) monoclonal antibody a valuable tool for researchers studying these pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

UGP2 Antibody (B-3) References:

1. Overexpression of human UDP-glucose pyrophosphorylase rescues galactose-1-phosphate uridyltransferase-deficient yeast.  |  Lai, K. and Elsas, LJ. 2000. Biochem Biophys Res Commun. 271: 392-400. PMID: 10799308
2. Toward a blueprint for UDP-glucose pyrophosphorylase structure/function properties: homology-modeling analyses.  |  Geisler, M., et al. 2004. Plant Mol Biol. 56: 783-94. PMID: 15803415
3. [Preparation and identification of monoclonal antibody against UGP2].  |  Wang, W., et al. 2007. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 15: 563-6. PMID: 17605866
4. Assignment of a molecular form of UDP glucose pyrophosphorylase (UGPP2) to chromosome 2 in man.  |  Shows, TB., et al. 1978. Cytogenet Cell Genet. 22: 215-8. PMID: 752477
5. Cloning of a human liver UDP-glucose pyrophosphorylase cDNA by complementation of the bacterial galU mutation.  |  Peng, HL. and Chang, HY. 1993. FEBS Lett. 329: 153-8. PMID: 8354390
6. The importance of conserved residues in human liver UDPglucose pyrophosphorylase.  |  Chang, HY., et al. 1996. Eur J Biochem. 236: 723-8. PMID: 8612650
7. Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli.  |  Duggleby, RG., et al. 1996. Eur J Biochem. 235: 173-9. PMID: 8631325
8. An improved assay for UDPglucose pyrophosphorylase and other enzymes that have nucleotide products.  |  Duggleby, RG., et al. 1996. Experientia. 52: 568-72. PMID: 8698091
9. Localization of the human UGP2 gene encoding the muscle isoform of UDPglucose pyrophosphorylase to 2p13-p14 by fluorescence in situ hybridization.  |  Cheng, SD., et al. 1997. Genomics. 39: 414-6. PMID: 9119383

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UGP2 Antibody (B-3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-UGP2 Antibody (B-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UGP2 Antibody (B-3) Specifications

Alternate Product Name: UGP2

Product Clone Name: B-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: UGP2

Epitope Species: human

Product Reactivity/Detection: UGP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for UGP2 Antibody (B-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin