Rab 3A Antibody (D-1): sc-271735
- Rab 3A Antibody (D-1) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 195-220 within the C-terminus of Rab 3A of human origin
- recommended for detection of Rab 3A of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rab 3A Antibody (D-1). This work is in progress.
Rab 3A Antibody (D-1) is a mouse monoclonal IgM antibody that detects Rab 3A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rab 3A is a member of the Rab family of small GTPases, which play a crucial role in the regulation of vesicle trafficking within cells. Specifically, Rab 3A is predominantly located in neuronal tissues and is essential for the exocytosis of neurotransmitters from synaptic vesicles, making Rab 3A vital for proper synaptic function and communication between neurons. The precise regulation of Rab 3A activity is critical, as dysregulation can lead to various neurological disorders, highlighting Rab 3A′s importance in maintaining synaptic integrity and neurotransmission. Anti-Rab 3A antibody (D-1) provides a reliable tool for researchers studying the dynamics of vesicle transport and the underlying mechanisms of synaptic transmission, facilitating advancements in our understanding of neuronal communication and related pathologies.
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Rab 3A Antibody (D-1) References:
- GTP binds to Rab3A in a complex with Ca2+/calmodulin. | Park, JB., et al. 2002. Biochem J. 362: 651-7. PMID: 11879192
- Differential dynamics of Rab3A and Rab27A on secretory granules. | Handley, MT., et al. 2007. J Cell Sci. 120: 973-84. PMID: 17311845
- Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1. | Huang, CC., et al. 2011. Traffic. 12: 1356-70. PMID: 21689256
- Rab3A, a possible marker of cortical granules, participates in cortical granule exocytosis in mouse eggs. | Bello, OD., et al. 2016. Exp Cell Res. 347: 42-51. PMID: 27423421
- Molecular and functional interactions of alpha-synuclein with Rab3a. | Lv, G., et al. 2022. J Biol Chem. 298: 102239. PMID: 35809645
- RAB3A Regulates Melanin Exocytosis and Transfer Induced by Keratinocyte-Conditioned Medium. | Cabaço, LC., et al. 2022. JID Innov. 2: 100139. PMID: 36090299
- zDHHC9 Regulates Cardiomyocyte Rab3a Activity and Atrial Natriuretic Peptide Secretion Through Palmitoylation of Rab3gap1. | Essandoh, K., et al. 2023. JACC Basic Transl Sci. 8: 518-542. PMID: 37325411
- Rab3A GTPase-activating protein-inhibiting activity of Rabphilin-3A, a putative Rab3A target protein. | Kishida, S., et al. 1993. J Biol Chem. 268: 22259-61. PMID: 8226731
- Mutants of Rab3A analogous to oncogenic Ras mutants. Sensitivity to Rab3A-GTPase activating protein and Rab3A-guanine nucleotide releasing factor. | Brondyk, WH., et al. 1993. J Biol Chem. 268: 9410-5. PMID: 8387493
- Role of Rab3a in neurotransmitter and hormone release: a discussion of recent data. | Henry, JP., et al. 1996. Biochem Soc Trans. 24: 657-61. PMID: 8878821
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rab 3A Antibody (D-1) | sc-271735 | 200 µg/ml | $316.00 | |||
Rab 3A (D-1) Neutralizing Peptide | sc-271735 P | 100 µg/0.5 ml | $68.00 |