ITM2B Antibody (C-8): sc-374362
- ITM2B Antibody (C-8) is a mouse monoclonal IgG2a κ ITM2B antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 1-54 mapping at the N-terminus of ITM2B of human origin
- ITM2B Antibody (C-8) is recommended for detection of ITM2B of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-ITM2B Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of ITM2B (C-8): sc-374362.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for ITM2B Antibody (C-8) for WB and IHC(P) applications. These reagents are now offered in bundles with ITM2B Antibody (C-8) (see ordering information below).
QUICK LINKS
ITM2B Antibody (C-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects ITM2B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-ITM2B antibody (C-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ITM2B, consisting of 266 amino acids, plays a crucial role in the central nervous system, where ITM2B is predominantly expressed. ITM2B features a potential N-glycosylation site and a single transmembrane-spanning domain, which are essential for function in cellular signaling and membrane interactions. These structural elements influence ITM2B′s stability and interactions with other cellular components. Notably, mutations in ITM2B are linked to familial British dementia and familial Danish dementia, both autosomal dominant disorders that manifest with severe neurological symptoms, including dementia and ataxia. ITM2B (C-8) monoclonal antibody′s ability to effectively detect ITM2B across various applications makes this tool invaluable for researchers studying implications in neurodegenerative diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ITM2B Antibody (C-8) References:
- A stop-codon mutation in the BRI gene associated with familial British dementia. | Vidal, R., et al. 1999. Nature. 399: 776-81. PMID: 10391242
- Systemic amyloid deposits in familial British dementia. | Ghiso, JA., et al. 2001. J Biol Chem. 276: 43909-14. PMID: 11557758
- Extensive analysis of the 13q14 region in human prostate tumors: DNA analysis and quantitative expression of genes lying in the interval of deletion. | Latil, A., et al. 2003. Prostate. 57: 39-50. PMID: 12886522
- Properties of neurotoxic peptides related to the Bri gene. | El-Agnaf, O., et al. 2004. Protein Pept Lett. 11: 207-12. PMID: 15182222
- All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo. | Zirn, B., et al. 2005. Oncogene. 24: 5246-51. PMID: 15897880
- Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia. | Morelli, L., et al. 2005. Biochem Biophys Res Commun. 332: 808-16. PMID: 15913558
- The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. | Matsuda, S., et al. 2005. J Biol Chem. 280: 28912-6. PMID: 15983050
- Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma. | Creytens, D., et al. 2014. Virchows Arch. 465: 97-108. PMID: 24659226
- Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. | Choi, H., et al. 2015. Biol Reprod. 93: 70. PMID: 26246218
- Generalised Anxiety Disorder--A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression. | Davies, MN., et al. 2015. PLoS One. 10: e0134865. PMID: 26274327
- G-MDSCs-Derived Exosomal miRNA-143-3p Promotes Proliferation via Targeting of ITM2B in Lung Cancer. | Zhou, JH., et al. 2020. Onco Targets Ther. 13: 9701-9719. PMID: 33061450
- Luria testing in demented patients. | Ernst, B., et al. 1970. Acta Neurol Scand. 46: 97-8. PMID: 5466275
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ITM2B Antibody (C-8) | sc-374362 | 200 µg/ml | $316.00 | |||
ITM2B Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-525958 | 200 µg Ab; 10 µg BP | $354.00 | |||
ITM2B Antibody (C-8): m-IgG2a BP-HRP Bundle | sc-546469 | 200 µg Ab; 10 µg BP | $354.00 | |||
ITM2B Antibody (C-8) AC | sc-374362 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ITM2B Antibody (C-8) HRP | sc-374362 HRP | 200 µg/ml | $316.00 | |||
ITM2B Antibody (C-8) FITC | sc-374362 FITC | 200 µg/ml | $330.00 | |||
ITM2B Antibody (C-8) PE | sc-374362 PE | 200 µg/ml | $343.00 | |||
ITM2B Antibody (C-8) Alexa Fluor® 488 | sc-374362 AF488 | 200 µg/ml | $357.00 | |||
ITM2B Antibody (C-8) Alexa Fluor® 546 | sc-374362 AF546 | 200 µg/ml | $357.00 | |||
ITM2B Antibody (C-8) Alexa Fluor® 594 | sc-374362 AF594 | 200 µg/ml | $357.00 | |||
ITM2B Antibody (C-8) Alexa Fluor® 647 | sc-374362 AF647 | 200 µg/ml | $357.00 | |||
ITM2B Antibody (C-8) Alexa Fluor® 680 | sc-374362 AF680 | 200 µg/ml | $357.00 | |||
ITM2B Antibody (C-8) Alexa Fluor® 790 | sc-374362 AF790 | 200 µg/ml | $357.00 |