NALP2 Antibody (E-5): sc-365935

NALP2 Antibody (E-5) is a mouse monoclonal IgG1 antibody that detects NALP2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NALP2 is a 1,062 amino acid protein that plays a critical role in regulating inflammatory responses by catalyzing the suppression of tumor necrosis factor (TNF) and CD40-induced nuclear factor kappa B (NFKB1) activity at the level of the IKK complex, specifically by inhibiting the degradation of NFKBIA induced by TNF. This regulation is vital for maintaining cellular homeostasis and preventing excessive inflammation, which can lead to various diseases. NALP2 is predominantly expressed in lung, placenta, and thymus tissues, with lower expression levels found in the ovary, intestine, and brain, highlighting its importance in immune and inflammatory processes. Structurally, NALP2 contains one DAPIN domain, nine leucine-rich repeats (LRR), and one NACHT domain, with the DAPIN domain being essential for its function in suppressing NFKB1 activation and inducing the secretion of the proinflammatory cytokine IL1B in collaboration with caspase-1. anti-NALP2 antibody (E-5) is an invaluable tool for researchers studying the mechanisms of inflammation and immune response in human tissues.

The preferred NALP2 antibody is NALP2 Antibody (H-4): sc-166584.