NPY Antibody (F-6): sc-133080

NPY Antibody (F-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects NPY protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-NPY antibody (F-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neuropeptide Y (NPY), consisting of 36 amino acids, plays a crucial role in regulating energy balance and appetite control, making NPY significant in understanding metabolic disorders and obesity. NPY is primarily located in the central and peripheral nervous systems, particularly in deep layers of the cortex and smaller cell bodies in white matter, where NPY is involved in modulating various physiological processes. NPY′s structure features a polyproline stretch followed by an amphipathic α-helix, which is essential for interaction with Y-receptor family of G protein-coupled receptors. NPY interacts with Y1 receptor to influence corticotropin levels and noradrenaline release in hypothalamus, thereby playing a vital role in stimulating food intake and promoting energy storage through increased lipoprotein lipase activity in white adipose tissue. A polymorphism at Leucine 7 to Proline 7 has been associated with increased alcohol preference and altered cholesterol metabolism, highlighting NPY′s importance in both behavioral and metabolic pathways.

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NPY Antibody (F-6) References:

1. Molecular characterization of the ligand-receptor interaction of the neuropeptide Y family.  |  Cabrele, C. and Beck-Sickinger, AG. 2000. J Pept Sci. 6: 97-122. PMID: 10759209
2. Neuropeptide Y polymorphism and alcohol consumption in middle-aged men.  |  Kauhanen, J., et al. 2000. Am J Med Genet. 93: 117-21. PMID: 10869113
3. NPY Y1 receptors exert opposite effects on corticotropin releasing factor and noradrenaline overflow from the rat hypothalamus in vitro.  |  Hastings, JA., et al. 2001. Brain Res. 890: 32-7. PMID: 11164766
4. Localization of neuropeptide Y mRNA in neurons of human cerebral cortex by means of in situ hybridization with a complementary RNA probe.  |  Terenghi, G., et al. 1987. Proc Natl Acad Sci U S A. 84: 7315-8. PMID: 2444979
5. Neuropeptide Y (NPY) and posttraumatic stress disorder (PTSD): A translational update.  |  Schmeltzer, SN., et al. 2016. Exp Neurol. 284: 196-210. PMID: 27377319
6. Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases.  |  Duarte-Neves, J., et al. 2016. Neurobiol Dis. 95: 210-24. PMID: 27461050
7. Neuropeptide Y (NPY) promotes inflammation-induced tumorigenesis by enhancing epithelial cell proliferation.  |  Jeppsson, S., et al. 2017. Am J Physiol Gastrointest Liver Physiol. 312: G103-G111. PMID: 27856419
8. The Role of Neuropeptide Y (NPY) in Alcohol and Drug Abuse Disorders.  |  Robinson, SL. and Thiele, TE. 2017. Int Rev Neurobiol. 136: 177-197. PMID: 29056151
9. Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7.  |  Takeuchi, T., et al. 1986. J Clin Invest. 77: 1038-41. PMID: 3753985
10. Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine.  |  Minth, CD., et al. 1984. Proc Natl Acad Sci U S A. 81: 4577-81. PMID: 6589611
11. Solution structure of human neuropeptide Y.  |  Monks, SA., et al. 1996. J Biomol NMR. 8: 379-90. PMID: 9008359
12. Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels.  |  Karvonen, MK., et al. 1998. Nat Med. 4: 1434-7. PMID: 9846584

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NPY Antibody (F-6) has 26 citations in a variety of scientific publications.

Primary antibodies like Anti-NPY Antibody (F-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NPY Antibody (F-6) Specifications

Alternate Product Name: Neuropeptide Y

Product Clone Name: F-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-97

Epitope Target: NPY

Epitope Species: human

Product Reactivity/Detection: NPY

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 26 citations in various scientific publications

Available Conjugates/Forms for NPY Antibody (F-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin