AIFL Antibody (A-9): sc-376570

AIFL Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects AIFL protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AIFL Antibody (A-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AIFL, or apoptosis-inducing factor-like, also known as AIFM3, is a 605 amino acid protein primarily localized to the mitochondrion, where AIFL plays a crucial role in apoptosis regulation. AIFL′s mitochondrial localization enables direct influence on mitochondrial membrane potential and facilitates pro-apoptotic factor release, initiating a caspase-dependent apoptotic pathway. AIFL′s function is vital for maintaining cellular homeostasis and preventing uncontrolled cell proliferation, which can lead to cancer. AIFL expression occurs in various tissues, including liver, thymus, ovary, bone marrow, and cerebral cortex, highlighting AIFL′s importance in diverse biological processes. AIFL′s encoding gene is located on human chromosome 22, a region associated with several genetic disorders, including Phelan-McDermid syndrome and Neurofibromatosis type 2, underscoring AIFL′s relevance in both health and disease.

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AIFL Antibody (A-9) References:

1. Disease genes and chromosomes: disease maps of the human genome. Chromosome 22.  |  Gilbert, F. 1998. Genet Test. 2: 89-97. PMID: 10464604
2. Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria.  |  Candé, C., et al. 2002. Biochimie. 84: 215-22. PMID: 12022952
3. Constitutional rearrangements of chromosome 22 as a cause of neurofibromatosis 2.  |  Tsilchorozidou, T., et al. 2004. J Med Genet. 41: 529-34. PMID: 15235024
4. Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis.  |  Xie, Q., et al. 2005. J Biol Chem. 280: 19673-81. PMID: 15764604
5. AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells.  |  Urbano, A., et al. 2005. EMBO J. 24: 2815-26. PMID: 16001080
6. Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia.  |  Arinami, T. 2006. J Hum Genet. 51: 1037-1045. PMID: 16969581
7. H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria.  |  Ashktorab, H., et al. 2008. Helicobacter. 13: 506-17. PMID: 19166416
8. First report on the gastropod proapoptotic AIF3 counterpart from disk abalone (Haliotis discus discus) deciphering its transcriptional modulation by induced pathogenic stress.  |  Elvitigala, DA., et al. 2015. Fish Shellfish Immunol. 47: 697-705. PMID: 26455649
9. CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney Development.  |  Lozic, M., et al. 2021. Int J Mol Sci. 22: PMID: 34502088
10. Bioinformatic Prediction of Novel Signaling Pathways of Apoptosis-inducing Factor, Mitochondrion-associated 3 (AIFM3) and Their Roles in Metastasis of Cholangiocarcinoma Cells.  |  Chua-On, D., et al. 2022. Cancer Genomics Proteomics. 19: 35-49. PMID: 34949658
11. Molecularly defined and functionally distinct cholinergic subnetworks.  |  Li, X., et al. 2022. Neuron. 110: 3774-3788.e7. PMID: 36130594
12. Molecular characterization of mitochondrial apoptosis-inducing factor.  |  Susin, SA., et al. 1999. Nature. 397: 441-6. PMID: 9989411

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AIFL Antibody (A-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AIFL Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AIFL Antibody (A-9) Specifications

Alternate Product Name: AIFL

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: AIFL

Epitope Species: human

Product Reactivity/Detection: AIFL

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AIFL Antibody (A-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin