PMCA1 Antibody (F-10): sc-398413
- PMCA1 Antibody (F-10) is a mouse monoclonal IgG1 κ PMCA1 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 5-62 mapping near the N-terminus of PMCA1 of human origin
- PMCA1 Antibody (F-10) is recommended for detection of PMCA1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PMCA1 Antibody (F-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PMCA1 (F-10): sc-398413.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PMCA1 Antibody (F-10). This work is in progress.
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PMCA1 Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects PMCA1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PMCA1 (F-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PMCA1 protein, also known as ATP2B1, plays a critical role in maintaining calcium homeostasis within cells by mediating the export of bivalent calcium ions from eukaryotic cells. This function is vital for numerous cellular processes, including muscle contraction, neurotransmitter release, and cell signaling, as dysregulation of calcium levels can lead to various pathophysiological conditions. PMCA1 is ubiquitously expressed, and PMCA1 activity is finely tuned by the expression of different isoforms and splice variants, which are regulated in a developmental, tissue, and cell type-specific manner. The precise control of PMCA1 expression and function is essential for the spatial and temporal regulation of intracellular calcium concentrations, thereby influencing the overall calcium signaling pathways that are crucial for cellular function and health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PMCA1 Antibody (F-10) References:
- Plasma membrane calcium ATPase isoforms in astrocytes. | Fresu, L., et al. 1999. Glia. 28: 150-5. PMID: 10533058
- Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. | Strehler, EE. and Zacharias, DA. 2001. Physiol Rev. 81: 21-50. PMID: 11152753
- Delayed activation of the plasma membrane calcium pump by a sudden increase in Ca2+: fast pumps reside in fast cells. | Caride, AJ., et al. 2001. Cell Calcium. 30: 49-57. PMID: 11396987
- Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23. | Olson, S., et al. 1991. Genomics. 9: 629-41. PMID: 1674727
- Molecular cloning of a third isoform of the calmodulin-sensitive plasma membrane Ca2+-transporting ATPase that is expressed predominantly in brain and skeletal muscle. | Greeb, J. and Shull, GE. 1989. J Biol Chem. 264: 18569-76. PMID: 2530223
- Reduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice. | Ehara, Y., et al. 2018. Hypertens Res. 41: 699-707. PMID: 29950683
- Plasma membrane Ca2+ ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca2+ homeostasis in mice. | Korthals, M., et al. 2021. Eur J Immunol. 51: 594-602. PMID: 33098669
- ATP2B1 gene polymorphisms rs2681472 and rs17249754 are associated with susceptibility to hypertension and blood pressure levels: A systematic review and meta-analysis. | Xie, M., et al. 2021. Medicine (Baltimore). 100: e25530. PMID: 33847678
- De novo variants in ATP2B1 lead to neurodevelopmental delay. | Rahimi, MJ., et al. 2022. Am J Hum Genet. 109: 944-952. PMID: 35358416
- ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis. | Yang, X., et al. 2023. Allergol Immunopathol (Madr). 51: 17-26. PMID: 36916084
- Regulation of overexpression lncRNA ATP2B1-AS1 on lung adenocarcinoma progression. | Chen, S., et al. 2024. J Cardiothorac Surg. 19: 88. PMID: 38347625
- Targeting ATP2B1 impairs PI3K/Akt/FOXO signaling and reduces SARS-COV-2 infection and replication. | de Antonellis, P., et al. 2024. EMBO Rep. 25: 2974-3007. PMID: 38816514
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PMCA1 Antibody (F-10) | sc-398413 | 200 µg/ml | $316.00 | |||
PMCA1 Antibody (F-10) AC | sc-398413 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PMCA1 Antibody (F-10) HRP | sc-398413 HRP | 200 µg/ml | $316.00 | |||
PMCA1 Antibody (F-10) FITC | sc-398413 FITC | 200 µg/ml | $330.00 | |||
PMCA1 Antibody (F-10) PE | sc-398413 PE | 200 µg/ml | $343.00 | |||
PMCA1 Antibody (F-10) Alexa Fluor® 488 | sc-398413 AF488 | 200 µg/ml | $357.00 | |||
PMCA1 Antibody (F-10) Alexa Fluor® 546 | sc-398413 AF546 | 200 µg/ml | $357.00 | |||
PMCA1 Antibody (F-10) Alexa Fluor® 594 | sc-398413 AF594 | 200 µg/ml | $357.00 | |||
PMCA1 Antibody (F-10) Alexa Fluor® 647 | sc-398413 AF647 | 200 µg/ml | $357.00 | |||
PMCA1 Antibody (F-10) Alexa Fluor® 680 | sc-398413 AF680 | 200 µg/ml | $357.00 | |||
PMCA1 Antibody (F-10) Alexa Fluor® 790 | sc-398413 AF790 | 200 µg/ml | $357.00 |