PMCA3 Antibody (G-6): sc-390148
- PMCA3 Antibody (G-6) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1133-1167 near the C-terminus of PMCA3 of human origin
- Anti-PMCA3 Antibody (G-6) is recommended for detection of all isoforms of PMCA3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-PMCA3 Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PMCA3 (G-6): sc-390148.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for PMCA3 Antibody (G-6) for WB applications. These reagents are now offered in bundles with PMCA3 Antibody (G-6) (see ordering information below).
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PMCA3 Antibody (G-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects PMCA3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PMCA3 Antibody (G-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PMCA3 plays a crucial role in regulating intracellular calcium levels, which is vital for numerous cellular processes, including muscle contraction, neurotransmitter release, and cell signaling. PMCA3 is predominantly expressed in brain and skeletal muscle, where PMCA3 helps maintain calcium homeostasis by exporting calcium ions out of cells, thus preventing calcium overload that can lead to cellular dysfunction or apoptosis. Precise regulation of PMCA3 expression is essential for proper functioning of excitable tissues, as fluctuations in calcium levels can significantly impact neuronal excitability and muscle contraction. Understanding PMCA3 dynamics and isoforms is critical for elucidating mechanisms underlying various physiological and pathological conditions, making anti-PMCA3 antibody (G-6) an invaluable tool for researchers studying calcium signaling pathways in these tissues.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PMCA3 Antibody (G-6) References:
- Plasma membrane calcium ATPase isoforms in astrocytes. | Fresu, L., et al. 1999. Glia. 28: 150-5. PMID: 10533058
- Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function. | Garcia, ML. and Strehler, EE. 1999. Front Biosci. 4: D869-82. PMID: 10577388
- Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. | Strehler, EE. and Zacharias, DA. 2001. Physiol Rev. 81: 21-50. PMID: 11152753
- Delayed activation of the plasma membrane calcium pump by a sudden increase in Ca2+: fast pumps reside in fast cells. | Caride, AJ., et al. 2001. Cell Calcium. 30: 49-57. PMID: 11396987
- Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23. | Olson, S., et al. 1991. Genomics. 9: 629-41. PMID: 1674727
- Localization of the plasma membrane Ca(2+)-ATPase isoform PMCA3 in rat cerebellum, choroid plexus and hippocampus. | Eakin, TJ., et al. 1995. Brain Res Mol Brain Res. 29: 71-80. PMID: 7770003
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PMCA3 Antibody (G-6) | sc-390148 | 200 µg/ml | $316.00 | |||
PMCA3 Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-526127 | 200 µg Ab; 10 µg BP | $354.00 | |||
PMCA3 Antibody (G-6): m-IgG2a BP-HRP Bundle | sc-546508 | 200 µg Ab; 10 µg BP | $354.00 | |||
PMCA3 Antibody (G-6) AC | sc-390148 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PMCA3 Antibody (G-6) HRP | sc-390148 HRP | 200 µg/ml | $316.00 | |||
PMCA3 Antibody (G-6) FITC | sc-390148 FITC | 200 µg/ml | $330.00 | |||
PMCA3 Antibody (G-6) PE | sc-390148 PE | 200 µg/ml | $343.00 | |||
PMCA3 Antibody (G-6) Alexa Fluor® 488 | sc-390148 AF488 | 200 µg/ml | $357.00 | |||
PMCA3 Antibody (G-6) Alexa Fluor® 546 | sc-390148 AF546 | 200 µg/ml | $357.00 | |||
PMCA3 Antibody (G-6) Alexa Fluor® 594 | sc-390148 AF594 | 200 µg/ml | $357.00 | |||
PMCA3 Antibody (G-6) Alexa Fluor® 647 | sc-390148 AF647 | 200 µg/ml | $357.00 | |||
PMCA3 Antibody (G-6) Alexa Fluor® 680 | sc-390148 AF680 | 200 µg/ml | $357.00 | |||
PMCA3 Antibody (G-6) Alexa Fluor® 790 | sc-390148 AF790 | 200 µg/ml | $357.00 | |||
PMCA3 (G-6) Neutralizing Peptide | sc-390148 P | 100 µg/0.5 ml | $68.00 |