Bag-1 Antibody (E-2): sc-377454

Bag-1 Antibody (E-2) is a mouse monoclonal IgG1 antibody that detects Bag-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Bag-1 is a critical regulator of apoptosis, functioning as a Bcl-2-binding protein that enhances the protective effects of Bcl-2 against cell death. This interaction suggests that Bag-1 may play a pivotal role in determining cell fate under stress conditions, potentially influencing therapeutic strategies targeting apoptosis in various diseases, including cancer. Bag-1 can modulate the apoptotic response by stabilizing Bcl-2, thereby preventing the activation of pro-apoptotic factors. Understanding Bag-1 dynamics and interactions with other proteins in the Bcl-2 family is essential for elucidating complex mechanisms of cell survival and death, making anti-Bag-1 antibody (E-2) a valuable research tool for investigating these pathways.

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Bag-1 Antibody (E-2) References:

1. The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome.  |  Lüders, J., et al. 2000. J Biol Chem. 275: 4613-7. PMID: 10671488
2. DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation.  |  Sun, L., et al. 2008. Cancer Res. 68: 2726-35. PMID: 18413740
3. BAG-1 expression in normal endometrium, endometrial hyperplasia and endometrial cancer.  |  Song, JY., et al. 2008. Acta Obstet Gynecol Scand. 87: 862-7. PMID: 18704778
4. BAG-1 predicts patient outcome and tamoxifen responsiveness in ER-positive invasive ductal carcinoma of the breast.  |  Millar, EK., et al. 2009. Br J Cancer. 100: 123-33. PMID: 19066611
5. Different BAG-1 isoforms have distinct functions in modulating chemotherapeutic-induced apoptosis in breast cancer cells.  |  Liu, HY., et al. 2009. Acta Pharmacol Sin. 30: 235-41. PMID: 19151744
6. Expressions of the anti-apoptotic genes Bag-1 and Bcl-2 in colon cancer and their relationship.  |  Sun, N., et al. 2010. Am J Surg. 200: 341-5. PMID: 20409521
7. BAG-1L promotes keratinocyte differentiation in organotypic culture models and changes in relative BAG-1 isoform abundance may lead to defective stratification.  |  Hinitt, CA., et al. 2011. Exp Cell Res. 317: 2159-70. PMID: 21723279
8. Correlation between the expression of the BAG-1 gene and clinicopathologic factors in colorectal cancer.  |  Sun, NF., et al. 2011. J Cancer Res Clin Oncol. 137: 1419-24. PMID: 21809033
9. Antiapoptotic gene BAG-1 vector structure of RNA interference and endogenous targeted screening in colon cancer cell lines.  |  Sun, NF., et al. 2014. Tumour Biol. 35: 1057-63. PMID: 24061638
10. Expression of BAG-1 is closely related to cell differentiation and TNM stage in esophageal cancer and its downregulation inhibits the proliferation and invasion of human esophageal carcinoma cells.  |  Huang, B., et al. 2014. Oncol Rep. 32: 1441-6. PMID: 25069471

The preferred Bag-1 antibody is Bag-1 Antibody (3.10G3E2): sc-56003.