Bag-1 Antibody (19): sc-135844
- Bag-1 Antibody (19) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 155-258 of Bag-1 of human origin
- recommended for detection of Bag-1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bag-1 Antibody (19). This work is in progress.
Bag-1 Antibody (19) is a mouse monoclonal IgG1 antibody that detects Bag-1 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Bag-1 is a critical protein that plays a significant role in regulating apoptosis, acting as a Bcl-2-binding protein that enhances the protective effects of Bcl-2 against cell death. Anti-Bag-1 antibody (19) enables researchers to study a novel anti-apoptotic mechanism, potentially influencing therapeutic strategies in diseases characterized by dysregulated apoptosis, such as cancer. Bag-1′s ability to modulate Bcl-2 activity highlights its importance in maintaining cellular homeostasis and survival, particularly under stress conditions. By studying Bag-1 and its interactions using Bag-1 monoclonal antibody (19), researchers can gain insights into the complex pathways governing cell death and survival, paving the way for innovative approaches in targeted therapies.
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Bag-1 Antibody (19) References:
- Bag-1 up-regulation in anti-CD4 mAb treated allo-activated T cells confers resistance to apoptosis. | Sawitzki, B., et al. 2002. Eur J Immunol. 32: 800-9. PMID: 11870624
- Biological activities of HAP46/BAG-1. The HAP46/BAG-1 protein: regulator of HSP70 chaperones, DNA-binding protein and stimulator of transcription. | Gehring, U. 2004. EMBO Rep. 5: 148-53. PMID: 14755308
- The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. | Clemo, NK., et al. 2005. Biochem Soc Trans. 33: 676-8. PMID: 16042572
- The BAG-1 cochaperone is a negative regulator of p73-dependent transcription. | Wang, XH., et al. 2009. Br J Cancer. 100: 1347-57. PMID: 19293798
- BAG-1 enhances cell-cell adhesion, reduces proliferation and induces chaperone-independent suppression of hepatocyte growth factor-induced epidermal keratinocyte migration. | Hinitt, CA., et al. 2010. Exp Cell Res. 316: 2042-60. PMID: 20430025
- BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor β (TGF-β1) in colorectal tumour cells. | Skeen, VR., et al. 2013. Oncogene. 32: 4490-9. PMID: 23108401
- The BAG-1 isoform BAG-1M regulates keratin-associated Hsp70 chaperoning of aPKC in intestinal cells during activation of inflammatory signaling. | Mashukova, A., et al. 2014. J Cell Sci. 127: 3568-77. PMID: 24876225
- MiR-138 Suppresses Cell Proliferation by Targeting Bag-1 in Gallbladder Carcinoma. | Ma, F., et al. 2015. PLoS One. 10: e0126499. PMID: 25962180
- The comparison of differentially expressed microRNAs in Bag-1 deficient and wild type MCF-7 breast cancer cells by small RNA sequencing. | Özfiliz Kilbaş, P., et al. 2022. Turk J Biol. 46: 118-136. PMID: 37533517
- BAG-1 modulates the chaperone activity of Hsp70/Hsc70. | Takayama, S., et al. 1997. EMBO J. 16: 4887-96. PMID: 9305631
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bag-1 Antibody (19) | sc-135844 | 50 µg/0.5 ml | $316.00 |