CD2 Antibody (UMCD2): sc-65247
- CD2 Antibody (UMCD2) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against rheumatoid synovial T cell line ST-1 of human origin
- recommended for detection of CD2 of human origin by WB, IP, IF and FCM
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for CD2 Antibody (UMCD2) for WB applications. These reagents are now offered in bundles with CD2 Antibody (UMCD2) (see ordering information below).
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CD2 Antibody (UMCD2) is a mouse monoclonal IgG2a antibody that detects CD2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD2 is a crucial transmembrane glycoprotein primarily expressed on peripheral blood T lymphocytes, natural killer (NK) cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD2 mediates cell adhesion by interacting with CD58, which enhances antigen-specific T cell activation. This interaction is vital for optimizing immune system recognition, as CD2 facilitates communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. The importance of CD2 in immune responses underscores CD2′s potential as a therapeutic target in various immunological disorders. Anti-CD2 antibody (UMCD2) provides a reliable tool for researchers studying T cell activation and immune interactions, contributing to a deeper understanding of immune system dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD2 Antibody (UMCD2) References:
- Acute stress impairs NK cell adhesion and cytotoxicity through CD2, but not LFA-1. | Rogers, CJ., et al. 1999. J Neuroimmunol. 99: 230-41. PMID: 10505980
- Coordinate regulation of T cell activation by CD2 and CD28. | Green, JM., et al. 2000. J Immunol. 164: 3591-5. PMID: 10725714
- Priming of CD2-induced p62Dok tyrosine phosphorylation by CD3 in Jurkat T cells. | Harriague, J., et al. 2000. Eur J Immunol. 30: 3319-28. PMID: 11093148
- The interferon-inducible Staf50 gene is downregulated during T cell costimulation by CD2 and CD28. | Gongora, C., et al. 2000. J Interferon Cytokine Res. 20: 955-61. PMID: 11096452
- p62dok negatively regulates CD2 signaling in Jurkat cells. | Némorin, JG., et al. 2001. J Immunol. 166: 4408-15. PMID: 11254695
- CD2-SLFA3/T11TS interaction facilitates immune activation and glioma regression by apoptosis. | Sarkar, S., et al. 2004. Cancer Biol Ther. 3: 1121-8. PMID: 15467439
- Structure-based rational design of beta-hairpin peptides from discontinuous epitopes of cluster of differentiation 2 (CD2) protein to modulate cell adhesion interaction. | Liu, J., et al. 2007. J Med Chem. 50: 4038-47. PMID: 17658775
- Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates. | Brady, JL., et al. 2009. Immunol Cell Biol. 87: 413-8. PMID: 19204736
- Structural and functional characterization of the CD2 immunoadhesion domain. Evidence for inclusion of CD2 in an alpha-beta protein folding class. | Recny, MA., et al. 1990. J Biol Chem. 265: 8542-9. PMID: 1971273
- CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail. | King, PD., et al. 1998. Int Immunol. 10: 1009-16. PMID: 9701039
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD2 Antibody (UMCD2) | sc-65247 | 200 µg/ml | $316.00 | |||
CD2 Antibody (UMCD2): m-IgG Fc BP-HRP Bundle | sc-539162 | 200 µg Ab; 10 µg BP | $354.00 | |||
CD2 Antibody (UMCD2): m-IgG2a BP-HRP Bundle | sc-546675 | 200 µg Ab; 10 µg BP | $354.00 |