CD28 Antibody (2Q1293): sc-70611
- CD28 Antibody (2Q1293) is a rat monoclonal IgG2b provided at 200 µg/ml
- raised against CD28 of human origin
- recommended for detection of CD28 of human origin by WB, IP, IF and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD28 Antibody (2Q1293). This work is in progress.
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CD28 Antibody (2Q1293) is a rat monoclonal IgG2b antibody that detects CD28 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD28 plays a crucial role in T cell activation and survival by providing essential co-stimulatory signals upon binding to CD80 and CD86 ligands, which are expressed on antigen-presenting cells. This interaction is vital for the full activation of T cells, as CD28 enhances proliferation and cytokine production, ultimately influencing the adaptive immune response. CD28 is predominantly expressed on resting T cells, while CTLA-4 serves as a negative regulator and is upregulated on activated T cells, highlighting the delicate balance of immune activation and inhibition. Anti-CD28 antibody (2Q1293) is instrumental in studying T cell dynamics and understanding the mechanisms underlying immune responses, making CD28 (2Q1293) monoclonal antibody an invaluable tool for researchers investigating immunological pathways and potential therapeutic targets.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD28 Antibody (2Q1293) References:
- Mechanism for down-regulation of CD28 by Nef. | Swigut, T., et al. 2001. EMBO J. 20: 1593-604. PMID: 11285224
- The immunological synapse and CD28-CD80 interactions. | Bromley, SK., et al. 2001. Nat Immunol. 2: 1159-66. PMID: 11713465
- Translocation of CD28 to lipid rafts and costimulation of IL-2. | Sadra, A., et al. 2004. Proc Natl Acad Sci U S A. 101: 11422-7. PMID: 15280538
- Memory T cells need CD28 costimulation to remember. | Boesteanu, AC. and Katsikis, PD. 2009. Semin Immunol. 21: 69-77. PMID: 19268606
- CD28 expression redefines thymocyte development during the pre-T to DP transition. | Teague, TK., et al. 2010. Int Immunol. 22: 387-97. PMID: 20203098
- CD28 proximal promoter polymorphisms in systemic lupus erythematosus susceptibility. | Brambila-Tapia, AJ., et al. 2012. Rheumatol Int. 32: 2165-8. PMID: 21544637
- Characterization and clinical relevance of circulating CD4+CD28- T cells in Graves' disease. | Wang, F., et al. 2015. Immunol Lett. 165: 47-51. PMID: 25839128
- Belatacept-Resistant Rejection Is Associated With CD28+ Memory CD8 T Cells. | Mathews, DV., et al. 2017. Am J Transplant. 17: 2285-2299. PMID: 28502128
- Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions. | Yoshida, N., et al. 2020. Blood. 135: 1467-1471. PMID: 31961925
- IL-21 Prevents Expansion of CD8+CD28- T Cells Stimulated by IL-15 and Changes Their Subset Distribution. | Xie, L., et al. 2021. Transplant Proc. 53: 2407-2414. PMID: 34474914
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD28 Antibody (2Q1293) | sc-70611 | 200 µg/ml | $316.00 |