CD32-A/B/C Antibody (C-7): sc-166578
- CD32-A/B/C Antibody (C-7) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-206 mapping at the N-terminus of CD32 of human origin
- recommended for detection of CD32-A, CD32-B and CD32-C of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD32-A/B/C Antibody (C-7) for WB applications. These reagents are now offered in bundles with CD32-A/B/C Antibody (C-7) (see ordering information below).
CD32-A/B/C Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects CD32 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD32, also known as Fc gamma RII, serves as a low-affinity receptor for the Fc fragment of aggregated immunoglobulin G (IgG), playing a crucial role in the immune response by facilitating the clearance of immune complexes through macrophages. This function is vital for maintaining immune homeostasis and preventing autoimmune diseases, as CD32 helps regulate the levels of circulating antibodies. CD32 exists in several isoforms, produced by alternative splicing of three distinct genes (A, B, and C), which include FcgRIIA, FcgRIIB1, FcgRIIB3, and FcgRIIC. These isoforms are expressed on various immune cells, including monocytes, placental trophoblasts, endothelial cells, and B lymphocytes, with specific isoforms like FcgRIIA and FcgRIIC also found on neutrophils. The diverse expression and functionality of CD32 isoforms underscore their importance in modulating immune responses and highlight the significance of CD32-A/B/C (C-7) antibody in research and clinical applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD32-A/B/C Antibody (C-7) References:
- CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir. | Badia, R., et al. 2018. Nat Commun. 9: 2739. PMID: 30013105
- The role of CD32 during HIV-1 infection. | Bertagnolli, LN., et al. 2018. Nature. 561: E17-E19. PMID: 30232425
- The Human FcγRII (CD32) Family of Leukocyte FcR in Health and Disease. | Anania, JC., et al. 2019. Front Immunol. 10: 464. PMID: 30941127
- CD32+CD4+ T Cells Are Highly Enriched for HIV DNA and Can Support Transcriptional Latency. | Darcis, G., et al. 2020. Cell Rep. 30: 2284-2296.e3. PMID: 32075737
- CD32+CD4+ memory T cells are enriched for total HIV-1 DNA in tissues from humanized mice. | Adams, P., et al. 2021. iScience. 24: 101881. PMID: 33364576
- CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues. | Huot, N., et al. 2021. Front Immunol. 12: 695148. PMID: 34220857
- Direct CD32 T-cell cytotoxicity: implications for breast cancer prognosis and treatment. | Sconocchia, G., et al. 2022. Life Sci Alliance. 5: PMID: 36241426
- CD32 Expression by CD4+ T and CD8+ T Lymphocytes Is Increased in Patients with Chronic Hepatitis B Virus Infection. | Yao, CY., et al. 2023. Viral Immunol. 36: 351-359. PMID: 37289774
- CD32 (FcγRIIB) expression is low on CD21low B cells from systemic sclerosis patients with digital ulcers, interstitial lung disease, and anti-topoisomerase I autoantibodies. | Kourkouni, E., et al. 2024. Clin Immunol. 262: 110195. PMID: 38494058
- CD32 captures committed haemogenic endothelial cells during human embryonic development. | Scarfò, R., et al. 2024. Nat Cell Biol. 26: 719-730. PMID: 38594587
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD32-A/B/C Antibody (C-7) | sc-166578 | 200 µg/ml | $316.00 | |||
CD32-A/B/C Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-540123 | 200 µg Ab; 10 µg BP | $354.00 | |||
CD32-A/B/C Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-541917 | 200 µg Ab; 20 µg BP | $354.00 |