CD33 Antibody (6C5/2): sc-53199
- CD33 Antibody (6C5/2) is a mouse monoclonal IgG1 κ CD33 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant CD33 of human origin
- CD33 Antibody (6C5/2) is recommended for detection of CD33 of mouse, rat and human origin by WB, IP and FCM
- Anti-CD33 Antibody (6C5/2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of CD33 (6C5/2): sc-53199.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD33 Antibody (6C5/2). This work is in progress.
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SEE ALSO...
CD33 Antibody (6C5/2) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD33 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD33 (6C5/2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD33, also known as SIGLEC3, is a type I transmembrane glycoprotein primarily located on the surface of granulocyte and macrophage precursors in the bone marrow, while being absent from pluripotent stem cells. Expression on monocytes in peripheral blood makes CD33 a crucial marker for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. CD33 may function as a sialic acid-dependent cell adhesion molecule, which is important for mediating interactions between immune cells and their environment, thereby influencing immune responses and cell signaling pathways. Understanding CD33′s role in these processes can provide insights into potential therapeutic targets in various hematological malignancies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD33 Antibody (6C5/2) References:
- CD33 in Alzheimer's disease. | Jiang, T., et al. 2014. Mol Neurobiol. 49: 529-35. PMID: 23982747
- IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function. | Vallera, DA., et al. 2016. Clin Cancer Res. 22: 3440-50. PMID: 26847056
- Investigational CD33-targeted therapeutics for acute myeloid leukemia. | Walter, RB. 2018. Expert Opin Investig Drugs. 27: 339-348. PMID: 29534618
- Expanding use of CD33-directed immunotherapy. | Walter, RB. 2020. Expert Opin Biol Ther. 20: 955-958. PMID: 32580591
- Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation. | Griciuc, A., et al. 2020. Hum Mol Genet. 29: 2920-2935. PMID: 32803224
- CD33 directed bispecific antibodies in acute myeloid leukemia. | Clark, MC. and Stein, A. 2020. Best Pract Res Clin Haematol. 33: 101224. PMID: 33279180
- Bispecific CD33/CD123 targeted chimeric antigen receptor T cells for the treatment of acute myeloid leukemia. | Boucher, JC., et al. 2023. Mol Ther Oncolytics. 31: 100751. PMID: 38075241
- Dual-targeting CD33/CD123 NANOBODY T-cell engager with potent anti-AML activity and good safety profile. | Zeng, Z., et al. 2024. Blood Adv. 8: 2059-2073. PMID: 38266153
- Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing. | Appelbaum, J., et al. 2024. J Clin Invest. 134: PMID: 38502193
- Developing a membrane-proximal CD33-targeting CAR T cell. | Freeman, R., et al. 2024. J Immunother Cancer. 12: PMID: 38772686
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD33 Antibody (6C5/2) | sc-53199 | 200 µg/ml | $316.00 | |||
CD33 Antibody (6C5/2) AC | sc-53199 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CD33 Antibody (6C5/2) HRP | sc-53199 HRP | 200 µg/ml | $316.00 | |||
CD33 Antibody (6C5/2) FITC | sc-53199 FITC | 200 µg/ml | $330.00 | |||
CD33 Antibody (6C5/2) PE | sc-53199 PE | 200 µg/ml | $343.00 | |||
CD33 Antibody (6C5/2) Alexa Fluor® 488 | sc-53199 AF488 | 200 µg/ml | $357.00 | |||
CD33 Antibody (6C5/2) Alexa Fluor® 546 | sc-53199 AF546 | 200 µg/ml | $357.00 | |||
CD33 Antibody (6C5/2) Alexa Fluor® 594 | sc-53199 AF594 | 200 µg/ml | $357.00 | |||
CD33 Antibody (6C5/2) Alexa Fluor® 647 | sc-53199 AF647 | 200 µg/ml | $357.00 | |||
CD33 Antibody (6C5/2) Alexa Fluor® 680 | sc-53199 AF680 | 200 µg/ml | $357.00 | |||
CD33 Antibody (6C5/2) Alexa Fluor® 790 | sc-53199 AF790 | 200 µg/ml | $357.00 |