ERp57 Antibody (E-7): sc-133168
- ERp57 Antibody (E-7) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 108-207 mapping to an internal region of ERp57 of human origin
- recommended for detection of ERp57 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for ERp57 Antibody (E-7) for WB and IHC(P) applications. This reagent is now offered in a bundle with ERp57 Antibody (E-7) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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ERp57 Antibody (E-7) is a mouse monoclonal IgM antibody that detects ERp57 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ERp57, also known as GRP57, GRP58, ERp60, and ERp61, plays a crucial role in the major histocompatibility complex (MHC) class I pathway, which is essential for the immune response against intracellular pathogens. Anti-ERp57 antibody (E-7) targets a protein primarily located in the endoplasmic reticulum, where ERp57 assists in the proper folding and assembly of MHC class I molecules, ensuring effective presentation of antigenic peptides to cytotoxic T lymphocytes. ERp57 gene is located on chromosome 15q15 and encodes a 505 amino acid protein containing two highly conserved Trp-Cys-Gly-His-Cys-Lys motifs, underscoring evolutionary importance. ERp57 exhibits multifunctional properties, acting as a protease, protein disulfide isomerase, and potentially a phospholipase, which highlights significance in cellular processes. ERp57 (E-7) antibody serves as an invaluable tool for researchers studying immune responses and protein interactions in various biological contexts.
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ERp57 Antibody (E-7) References:
- ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin. | Oliver, JD., et al. 1999. Mol Biol Cell. 10: 2573-82. PMID: 10436013
- TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain. | Frickel, EM., et al. 2002. Proc Natl Acad Sci U S A. 99: 1954-9. PMID: 11842220
- ERp57-associated mitochondrial μ-calpain truncates apoptosis-inducing factor. | Ozaki, T., et al. 2008. Biochim Biophys Acta. 1783: 1955-63. PMID: 18559257
- Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57. | Ramírez-Rangel, I., et al. 2011. Mol Cell Biol. 31: 1657-71. PMID: 21321085
- Interaction of ERp57 with calreticulin: Analysis of complex formation and effects of vancomycin. | Frasconi, M., et al. 2012. Biophys Chem. 160: 46-53. PMID: 21996511
- Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer. | Chung, H., et al. 2013. Biomarkers. 18: 573-9. PMID: 23957851
- Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin. | Wang, L., et al. 2013. Blood. 122: 3642-50. PMID: 24030382
- Upregulation of ERp57 promotes clear cell renal cell carcinoma progression by initiating a STAT3/ILF3 feedback loop. | Liu, Y., et al. 2019. J Exp Clin Cancer Res. 38: 439. PMID: 31747963
- DT-010 Exerts Cardioprotective Effects by Regulating the Crosstalk between the AMPK/PGC-1α Pathway and ERp57. | Zhang, X., et al. 2023. Cardiovasc Ther. 2023: 8047752. PMID: 36817353
- Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERp57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells. | Parakh, S., et al. 2024. Neuromolecular Med. 26: 23. PMID: 38861223
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERp57 Antibody (E-7) | sc-133168 | 200 µg/ml | $316.00 | |||
ERp57 Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-550738 | 200 µg Ab; 40 µg BP | $354.00 |