Fgl2 Antibody (4H5): sc-100276
- Fgl2 Antibody (4H5) is a mouse monoclonal IgG2a κ Fgl2 antibody, cited in 8 publications, provided at 100 µg/ml
- raised against recombinant Fgl2 of human origin
- recommended for detection of Fibrinogen-like protein 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Fgl2 (4H5): sc-100276.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Fgl2 Antibody (4H5) for WB and IHC(P) applications. These reagents are now offered in bundles with Fgl2 Antibody (4H5) (see ordering information below).
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Fgl2 Antibody (4H5) is a mouse monoclonal IgG2a kappa light chain antibody that detects Fgl2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Fgl2 antibody (4H5) is available as the non-conjugated form. Fibrinogen-like protein 2 (Fgl2), also known as fibroleukin, plays a crucial role in the immune response and is secreted by T cells, particularly in contexts where thrombosis is significant, such as viral-induced fulminant hepatitis, fetal loss syndrome, and xenograft rejection. Fgl2 is primarily located in the cytoplasm of cytotoxic T-cells, where constitutive expression allows immunosuppressive effects on T cell proliferation and dendritic cell maturation. This localization enables Fgl2 to modulate immune responses effectively, particularly in inflammatory conditions. Additionally, Fgl2 functions as a serine protease, directly cleaving prothrombin to thrombin, which is essential for the coagulation cascade. Fgl2′s ability to influence both immune and coagulation pathways underscores its importance in the pathogenesis of various diseases, including viral-induced hepatitis and Th1 cytokine-induced fetal loss syndrome.
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Fgl2 Antibody (4H5) References:
- The nucleocapsid protein of murine hepatitis virus type 3 induces transcription of the novel fgl2 prothrombinase gene. | Ning, Q., et al. 1999. J Biol Chem. 274: 9930-6. PMID: 10187767
- Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: a novel human procoagulant. | Yuwaraj, S., et al. 2001. Genomics. 71: 330-8. PMID: 11170750
- Induction of prothrombinase fgl2 by the nucleocapsid protein of virulent mouse hepatitis virus is dependent on host hepatic nuclear factor-4 alpha. | Ning, Q., et al. 2003. J Biol Chem. 278: 15541-9. PMID: 12594208
- Soluble fibrinogen-like protein 2/fibroleukin exhibits immunosuppressive properties: suppressing T cell proliferation and inhibiting maturation of bone marrow-derived dendritic cells. | Chan, CW., et al. 2003. J Immunol. 170: 4036-44. PMID: 12682232
- Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection. | Ghanekar, A., et al. 2004. J Immunol. 172: 5693-701. PMID: 15100314
- Region-specific expression and secretion of the fibrinogen-related protein, fgl2, by epithelial cells of the hamster epididymis and its role in disposal of defective spermatozoa. | Olson, GE., et al. 2004. J Biol Chem. 279: 51266-74. PMID: 15377663
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fgl2 Antibody (4H5) | sc-100276 | 100 µg/ml | $333.00 | |||
Fgl2 Antibody (4H5): m-IgG Fc BP-HRP Bundle | sc-539679 | 100 µg Ab; 10 µg BP | $354.00 | |||
Fgl2 Antibody (4H5): m-IgG2a BP-HRP Bundle | sc-546748 | 100 µg Ab; 10 µg BP | $354.00 |