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GITR Antibody (621) is a mouse monoclonal IgG1 kappa light chain antibody that detects GITR protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). GITR (621) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) plays a crucial role in modulating immune responses, particularly in T lymphocytes, where GITR is preferentially expressed in the thymus, spleen, and lymph nodes. GITR is a member of the tumor necrosis factor receptor (TNFR) superfamily, which is characterized by type I transmembrane glycoproteins that are integral to various cellular functions, including proliferation, differentiation, and programmed cell death. The structure of GITR includes a cysteine-rich extracellular domain that facilitates ligand binding and an intracellular death domain that is essential for signal transduction. This structural configuration allows GITR to interact with other proteins in the TNFR superfamily, such as Ox40, 4-1BB, and CD27, thereby influencing the activation of critical signaling pathways like NFκB, which promotes cell survival, and caspase pathways, which lead to apoptosis. Understanding the structure and function of GITR is vital for developing therapeutic strategies aimed at enhancing or inhibiting immune responses in various diseases, including cancer and autoimmune disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GITR Antibody (621) | sc-53972 | 200 µg/ml | $316.00 | |||
GITR Antibody (621): m-IgG Fc BP-HRP Bundle | sc-526855 | 200 µg Ab; 10 µg BP | $354.00 | |||
GITR Antibody (621): m-IgG1 BP-HRP Bundle | sc-532228 | 200 µg Ab; 20 µg BP | $354.00 | |||
GITR Antibody (621) AC | sc-53972 AC | 500 µg/ml, 25% agarose | $416.00 | |||
GITR Antibody (621) HRP | sc-53972 HRP | 200 µg/ml | $316.00 | |||
GITR Antibody (621) FITC | sc-53972 FITC | 200 µg/ml | $330.00 | |||
GITR Antibody (621) PE | sc-53972 PE | 200 µg/ml | $343.00 | |||
GITR Antibody (621) Alexa Fluor® 488 | sc-53972 AF488 | 200 µg/ml | $357.00 | |||
GITR Antibody (621) Alexa Fluor® 546 | sc-53972 AF546 | 200 µg/ml | $357.00 | |||
GITR Antibody (621) Alexa Fluor® 594 | sc-53972 AF594 | 200 µg/ml | $357.00 | |||
GITR Antibody (621) Alexa Fluor® 647 | sc-53972 AF647 | 200 µg/ml | $357.00 | |||
GITR Antibody (621) Alexa Fluor® 680 | sc-53972 AF680 | 200 µg/ml | $357.00 | |||
GITR Antibody (621) Alexa Fluor® 790 | sc-53972 AF790 | 200 µg/ml | $357.00 |