HLA-A Antibody (B-11): sc-390473

HLA-A Antibody (B-11) is a mouse monoclonal IgM antibody that detects HLA-A of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). HLA-A Antibody (B-11) is available as the non-conjugated anti-HLA-A antibody (B-11). HLA-A plays a crucial role in the immune system as a member of the major histocompatibility complex (MHC) class I molecules, which are essential for presenting intracellular peptides to CD8+ T lymphocytes. This presentation is vital for the immune response, enabling recognition and elimination of infected or malignant cells. HLA-A is expressed on nearly all nucleated cells, facilitating surveillance of cellular health and integrity. Due to polymorphic nature, HLA-A presents diverse peptides critical for adaptive immune response, helping recognize various pathogens. Structural characteristics of HLA-A, including membrane-anchored heavy chain forming a heterodimer with β-2-Microglobulin, are fundamental to antigen presentation function. HLA-A polymorphisms result in numerous alleles, influencing individual immune responses and holding significance in transplantation and disease susceptibility studies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

HLA-A Antibody (B-11) References:

1. HIV's evasion of the cellular immune response.  |  Collins, KL. and Baltimore, D. 1999. Immunol Rev. 168: 65-74. PMID: 10399065
2. [Autoimmune thyroid disease induced by interferon therapy].  |  Murakami, M., et al. 1999. Nihon Rinsho. 57: 1779-83. PMID: 10483250
3. Creating HIV-1 reverse transcriptase cytotoxic T lymphocyte target structures by HLA-A2 heavy chain modifications.  |  Dela Cruz, CS., et al. 2000. Int Immunol. 12: 1293-302. PMID: 10967024
4. [Human tumor-rejection antigens and peptides from genes to clinical research].  |  Itoh, K., et al. 2000. Nihon Geka Gakkai Zasshi. 101: 612-7. PMID: 11022676
5. A general strategy to enhance immunogenicity of low-affinity HLA-A2. 1-associated peptides: implication in the identification of cryptic tumor epitopes.  |  Tourdot, S., et al. 2000. Eur J Immunol. 30: 3411-21. PMID: 11093159
6. Variations in the cytoplasmic region account for the heterogeneity of the chicken MHC class I (B-F) molecules.  |  Møller, LB., et al. 1991. Immunogenetics. 34: 110-20. PMID: 1869304
7. Ontogenic appearance of MHC class I (B-F) antigens during chicken embryogenesis.  |  Dunon, D., et al. 1990. Dev Immunol. 1: 127-35. PMID: 2136208
8. The chicken erythrocyte-specific MHC antigen. Characterization and purification of the B-G antigen by monoclonal antibodies.  |  Salomonsen, J., et al. 1987. Immunogenetics. 25: 373-82. PMID: 2439446
9. The role of HLA-A*33:01 in patients with cholestatic hepatitis attributed to terbinafine.  |  Fontana, RJ., et al. 2018. J Hepatol. 69: 1317-1325. PMID: 30138689
10. Identification of four novel HLA-A alleles.  |  Dard, C., et al. 2020. HLA. 96: 202-203. PMID: 32277603
11. Affinity Maturation of a T-Cell Receptor-Like Antibody Specific for a Cytomegalovirus pp65-Derived Peptide Presented by HLA-A*02:01.  |  Lee, SY., et al. 2021. Int J Mol Sci. 22: PMID: 33652936
12. [Correlative Analysis between Production of Platelet HLA-Ⅰ Antibody and HLA-A, B Genes in Patients with Malignant Hematological Diseases].  |  Gao, XY., et al. 2022. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 30: 1203-1207. PMID: 35981385

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HLA-A Antibody (B-11) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-HLA-A Antibody (B-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HLA-A Antibody (B-11) Specifications

Alternate Product Name: HLAA

Product Clone Name: B-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 26-45

Epitope Target: HLA-A

Epitope Species: human

Product Reactivity/Detection: a broad range of HLA antigens

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for HLA-A Antibody (B-11): P: Blocking Peptide

The preferred HLA class I antibody is HLA class I Antibody (HP-1F7): sc-69892.