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MHC class I Antibody (W6/32) is a mouse monoclonal IgG2a kappa light chain antibody that specifically detects HLA-A, HLA-B, and HLA-C molecules of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). MHC class I monoclonal antibody (W6/32) recognizes a monomorphic epitope present on the heavy chain of human MHC class I molecules, enabling broad detection of these essential cell surface proteins. MHC class I molecules, also known as human leukocyte antigens (HLA) class I, including HLA-A, HLA-B, and HLA-C, are crucial for the immune system′s ability to present endogenously derived peptide antigens to cytotoxic T lymphocytes (CD8+ T cells). By presenting peptides typically 8-10 amino acids in length, MHC class I molecules allow the immune system to monitor cellular health and identify infected or malignant cells. MHC class I molecules function is vital for immune surveillance and initiating cytotoxic immune responses, playing a key role in controlling viral infections and tumor development. Each MHC class I molecule is composed of a heavy alpha chain and a light chain called β2-microglobulin. The heavy alpha chain contains a peptide-binding groove that is essential for antigen presentation to cytotoxic T lymphocytes. The light chain, β2-microglobulin, is non-covalently associated with the alpha chain and is crucial for the proper folding, stability, and surface expression of the MHC class I complex. Dysregulation or downregulation of MHC class I expression can lead to immune evasion by pathogens or cancer cells, highlighting their importance in disease processes. MHC class I (W6/32) antibody serves as a valuable tool for researchers studying antigen presentation, immune recognition, and related immunological functions.
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Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MHC class I Antibody (W6/32) | sc-32235 | 200 µg/ml | $316.00 | |||
MHC class I Antibody (W6/32): m-IgG Fc BP-HRP Bundle | sc-528444 | 200 µg Ab; 10 µg BP | $354.00 | |||
MHC class I Antibody (W6/32): m-IgGκ BP-HRP Bundle | sc-520822 | 200 µg Ab, 40 µg BP | $354.00 | |||
MHC class I Antibody (W6/32): m-IgG2a BP-HRP Bundle | sc-547101 | 200 µg Ab; 10 µg BP | $354.00 | |||
MHC class I Antibody (W6/32) AC | sc-32235 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MHC class I Antibody (W6/32) HRP | sc-32235 HRP | 200 µg/ml | $316.00 | |||
MHC class I Antibody (W6/32) FITC | sc-32235 FITC | 200 µg/ml | $330.00 | |||
MHC class I Antibody (W6/32) PE | sc-32235 PE | 200 µg/ml | $343.00 | |||
MHC class I Antibody (W6/32) Alexa Fluor® 488 | sc-32235 AF488 | 200 µg/ml | $357.00 | |||
MHC class I Antibody (W6/32) Alexa Fluor® 546 | sc-32235 AF546 | 200 µg/ml | $357.00 | |||
MHC class I Antibody (W6/32) Alexa Fluor® 594 | sc-32235 AF594 | 200 µg/ml | $357.00 | |||
MHC class I Antibody (W6/32) Alexa Fluor® 647 | sc-32235 AF647 | 200 µg/ml | $357.00 | |||
MHC class I Antibody (W6/32) Alexa Fluor® 680 | sc-32235 AF680 | 200 µg/ml | $357.00 | |||
MHC class I Antibody (W6/32) Alexa Fluor® 790 | sc-32235 AF790 | 200 µg/ml | $357.00 | |||
MHC class I Antibody (W6/32) B | sc-32235 B | 200 µg/ml | $320.00 |