MHC class II Antibody (TE12): sc-73601
- MHC class II Antibody (TE12) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against stroma cells of human origin
- recommended for detection of MHC class II of human origin by IF
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MHC class II Antibody (TE12) for WB and IHC(P) applications. These reagents are now offered in bundles with MHC class II Antibody (TE12) (see ordering information below).
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MHC class II Antibody (TE12) is a mouse monoclonal IgG1 antibody that detects MHC class II in human samples through immunofluorescence (IF) applications. MHC class II molecules play a crucial role in the immune response by presenting processed exogenous antigens to helper T lymphocytes, which are essential for orchestrating adaptive immunity. These molecules are primarily located on the surface of antigen-presenting cells, such as dendritic cells, macrophages, and B cells, where they facilitate the activation of CD4+ T cells. The ability of MHC class II to bind longer peptide fragments, typically ranging from 13 to 18 amino acids, is vital for effective immune recognition and response. This structural characteristic allows for a diverse range of antigen presentation, which is critical for the immune system′s ability to recognize and respond to various pathogens. Anti-MHC class II antibody (TE12) is an invaluable tool for researchers studying immune responses, autoimmune diseases, and the mechanisms of T cell activation, providing insights into the complex interplay between the immune system and disease.
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MHC class II Antibody (TE12) References:
- Induction of MHC class II antigens on cells of the inner ear. | Gloddek, B., et al. 2002. Audiol Neurootol. 7: 317-23. PMID: 12463193
- Intracellular transport of MHC class II molecules. | Neefjes, JJ. and Ploegh, HL. 1992. Immunol Today. 13: 179-84. PMID: 1642756
- MHC class II exacerbates demyelination in vivo independently of T cells. | Hiremath, MM., et al. 2008. J Neuroimmunol. 203: 23-32. PMID: 18805594
- MHC class II transport at a glance. | Berger, AC. and Roche, PA. 2009. J Cell Sci. 122: 1-4. PMID: 19092054
- Role of MHC Class II genes in the pathogenesis of pemphigoid. | Zakka, LR., et al. 2011. Autoimmun Rev. 11: 40-7. PMID: 21782980
- MHC class II and non-MHC class II genes differentially influence humoral immunity to Bacillus anthracis lethal factor and protective antigen. | Garman, L., et al. 2012. Toxins (Basel). 4: 1451-67. PMID: 23342680
- MHC class II pathway mediates adipose inflammation. | Osório, J. 2013. Nat Rev Endocrinol. 9: 252. PMID: 23478326
- MHC class II invariant chains in antigen processing and presentation. | Koch, N., et al. 1989. Trends Biochem Sci. 14: 383-6. PMID: 2688204
- Invariant chain p41 mediates production of soluble MHC class II molecules. | Shishido, T., et al. 2019. Biochem Biophys Res Commun. 509: 216-221. PMID: 30587340
- Studying MHC Class II Presentation of Immobilized Antigen by B Lymphocytes. | Sáez, JJ., et al. 2019. Methods Mol Biol. 1988: 419-437. PMID: 31147956
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MHC class II Antibody (TE12) | sc-73601 | 200 µg/ml | $316.00 | |||
MHC class II Antibody (TE12): m-IgG Fc BP-HRP Bundle | sc-537226 | 200 µg Ab; 10 µg BP | $354.00 | |||
MHC class II Antibody (TE12): m-IgGκ BP-HRP Bundle | sc-534439 | 200 µg Ab; 40 µg BP | $354.00 | |||
MHC class II Antibody (TE12): m-IgG1 BP-HRP Bundle | sc-545091 | 200 µg Ab; 20 µg BP | $354.00 |