Siglec-5 (H-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects human Siglec-5 protein by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA). Siglec-5 (H-7) antibody is available unconjugated and in multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC) and various Alexa Fluor® conjugates. Two families of mammalian lectin-like adhesion molecules bind glycoconjugate ligands in a sialic acid-dependent manner: selectins and sialoadhesins. Sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members recognizing sialylated ligands. Siglec-5 binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. Four isoforms of hSiglec-5 exist with three (hSiglec-5-3L and -3C) or four (hSiglec-5-4L and -4S) extracellular domains linked to long (hSiglec-5-3L and -4L) or short (hSiglec-5-4S) cytoplasmic tails or as a soluble isoform (hSiglec-5-3C). Siglec-5 is expressed by monocytes and neutrophils, but is absent from leukemic cell lines representing early stages of myelomonocytic differentiation. Siglec-5 may play a role in diagnosing and monitoring acute myeloid leukemia (AML).
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Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Siglec-5 Antibody (H-7) | sc-377005 | 200 µg/ml | $316.00 | |||
Siglec-5 Antibody (H-7): m-IgG2a BP-HRP Bundle | sc-545951 | 200 µg Ab; 10 µg BP | $354.00 | |||
Siglec-5 Antibody (H-7) AC | sc-377005 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Siglec-5 Antibody (H-7) HRP | sc-377005 HRP | 200 µg/ml | $316.00 | |||
Siglec-5 Antibody (H-7) FITC | sc-377005 FITC | 200 µg/ml | $330.00 | |||
Siglec-5 Antibody (H-7) PE | sc-377005 PE | 200 µg/ml | $343.00 | |||
Siglec-5 Antibody (H-7) Alexa Fluor® 488 | sc-377005 AF488 | 200 µg/ml | $357.00 | |||
Siglec-5 Antibody (H-7) Alexa Fluor® 546 | sc-377005 AF546 | 200 µg/ml | $357.00 | |||
Siglec-5 Antibody (H-7) Alexa Fluor® 594 | sc-377005 AF594 | 200 µg/ml | $357.00 | |||
Siglec-5 Antibody (H-7) Alexa Fluor® 647 | sc-377005 AF647 | 200 µg/ml | $357.00 | |||
Siglec-5 Antibody (H-7) Alexa Fluor® 680 | sc-377005 AF680 | 200 µg/ml | $357.00 | |||
Siglec-5 Antibody (H-7) Alexa Fluor® 790 | sc-377005 AF790 | 200 µg/ml | $357.00 |