caspase-6 Antibody (14.1.190): sc-81653

Caspase-6 Antibody (14.1.190) is a mouse monoclonal IgG1 antibody that detects caspase-6 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Caspase-6 is a crucial member of the Ced-3/caspase family of cysteine proteases, which play a vital role in the apoptotic process by cleaving specific target proteins essential for cellular integrity and longevity. Notably, caspase-6 is involved in the cleavage of nuclear lamins, which are integral to maintaining the structural integrity of the nuclear envelope and ensuring proper cellular morphology. This function is particularly important during apoptosis, as the breakdown of nuclear lamins facilitates the disassembly of the nucleus, allowing for the orderly progression of programmed cell death. The ability of caspase-6 to interact with other caspases, such as caspase-3 and caspase-7, further underscores its significance in the apoptotic cascade, as caspase-6 can amplify the apoptotic signal in response to various stimuli. Anti-caspase-6 antibody (14.1.190) serves as an invaluable tool for researchers studying apoptosis and related cellular processes.

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caspase-6 Antibody (14.1.190) References:

1. Caspase-1 activation of caspase-6 in human apoptotic neurons.  |  Guo, H., et al. 2006. Cell Death Differ. 13: 285-92. PMID: 16123779
2. A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme.  |  Müller, I., et al. 2011. J Mol Biol. 410: 307-15. PMID: 21621544
3. Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke.  |  Akpan, N., et al. 2011. J Neurosci. 31: 8894-904. PMID: 21677173
4. Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.  |  Gafni, J., et al. 2012. J Neurosci. 32: 7454-65. PMID: 22649225
5. A synergic role of caspase-6 and caspase-3 in Tau truncation at D421 induced by H2O 2.  |  Zhao, H., et al. 2014. Cell Mol Neurobiol. 34: 369-78. PMID: 24363090
6. Identification of novel binding partners for caspase-6 using a proteomic approach.  |  Jung, JY., et al. 2014. J Microbiol Biotechnol. 24: 714-8. PMID: 24572280
7. Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons.  |  Ehrnhoefer, DE., et al. 2016. Exp Neurol. 283: 121-8. PMID: 27296315
8. Caspase-6 Induces 7A6 Antigen Localization to Mitochondria During FAS-induced Apoptosis of Jurkat Cells.  |  Suita, H., et al. 2017. Anticancer Res. 37: 1697-1704. PMID: 28373431
9. Understanding the molecular role of syndecan-1 in the regulation of caspase-6 during the progression of cardiac arrhythmia.  |  Wu, Y., et al. 2021. Exp Ther Med. 22: 1180. PMID: 34475970
10. Selective chemical reagents to investigate the role of caspase 6 in apoptosis in acute leukemia T cells.  |  Groborz, KM., et al. 2023. Chem Sci. 14: 2289-2302. PMID: 36873853

The preferred caspase-6 p10 antibody is caspase-6 p10 Antibody (H-12): sc-377393.