E-cadherin Antibody (DECMA-1): sc-59778
- E-cadherin Antibody (DECMA-1) is a rat monoclonal IgG1, cited in 65 publications, provided at 200 µg/ml
- raised against embryonal carcinoma cell line PCC4 Aza RI of mouse origin
- Anti-E-cadherin Antibody (DECMA-1) is recommended for detection of E-cadherin of mouse, rat, human and canine origin by WB, IP, IF and IHC(P)
- Anti-E-cadherin Antibody (DECMA-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of E-cadherin (DECMA-1): sc-59778.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for E-cadherin Antibody (DECMA-1). This work is in progress.
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SEE ALSO...
E-cadherin Antibody (DECMA-1) is a rat monoclonal IgG1 antibody that detects E-cadherin in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-E-cadherin antibody (DECMA-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. E-cadherin plays a crucial role in cell adhesion, acting as a key mediator of cell-cell interactions that are essential for maintaining tissue integrity and facilitating morphogenetic processes. E-cadherin is primarily located at the adherens junctions of epithelial cells, where E-cadherin forms homophilic interactions with neighboring E-cadherin molecules, thereby promoting strong adhesion between cells. Proper localization and function of E-cadherin are vital for the maintenance of epithelial tissue architecture, and dysregulation is often associated with various pathological conditions, including cancer metastasis. Classical cadherins, including E-cadherin, are characterized by large extracellular domains, which contain multiple homologous repeats that contribute to adhesive properties. E-cadherin′s intracellular domain interacts with cytoplasmic proteins such as β-catenin, linking E-cadherin to the actin cytoskeleton and playing a significant role in signaling pathways that regulate cell behavior.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E-cadherin Antibody (DECMA-1) | sc-59778 | 200 µg/ml | $316.00 | |||
E-cadherin Antibody (DECMA-1) AC | sc-59778 AC | 500 µg/ml, 25% agarose | $416.00 | |||
E-cadherin Antibody (DECMA-1) HRP | sc-59778 HRP | 200 µg/ml | $316.00 | |||
E-cadherin Antibody (DECMA-1) FITC | sc-59778 FITC | 200 µg/ml | $330.00 | |||
E-cadherin Antibody (DECMA-1) PE | sc-59778 PE | 200 µg/ml | $343.00 | |||
E-cadherin Antibody (DECMA-1) Alexa Fluor® 488 | sc-59778 AF488 | 200 µg/ml | $357.00 | |||
E-cadherin Antibody (DECMA-1) Alexa Fluor® 546 | sc-59778 AF546 | 200 µg/ml | $357.00 | |||
E-cadherin Antibody (DECMA-1) Alexa Fluor® 594 | sc-59778 AF594 | 200 µg/ml | $357.00 | |||
E-cadherin Antibody (DECMA-1) Alexa Fluor® 647 | sc-59778 AF647 | 200 µg/ml | $357.00 | |||
E-cadherin Antibody (DECMA-1) Alexa Fluor® 680 | sc-59778 AF680 | 200 µg/ml | $357.00 | |||
E-cadherin Antibody (DECMA-1) Alexa Fluor® 790 | sc-59778 AF790 | 200 µg/ml | $357.00 |