M-cadherin Antibody (C-8): sc-398107

M-cadherin Antibody (C-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects M-cadherin of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). M-cadherin Antibody (C-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. M-cadherin, also known as cadherin-15, belongs to the cadherin family of calcium-dependent cell adhesion molecules, which maintain tissue integrity and facilitate cell-cell interactions. M-cadherin primarily resides in skeletal muscle cells, where M-cadherin (C-8) antibody proves essential for myoblast fusion and muscle cell differentiation. M-cadherin expression remains notably low in fibroblasts but increases significantly during myotube formation, highlighting M-cadherin′s importance in muscle development and regeneration. M-cadherin′s extracellular domain contains five subdomains that mediate homophilic interactions, allowing precise adhesion necessary for muscle tissue architecture. Understanding M-cadherin′s function and regulation remains vital, as disruptions in M-cadherin expression or function can lead to muscle-related diseases and impairments in muscle regeneration.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

M-cadherin Antibody (C-8) References:

1. Frequent promoter methylation of M-cadherin in hepatocellular carcinoma is associated with poor prognosis.  |  Yamada, S., et al. 2007. Anticancer Res. 27: 2269-74. PMID: 17695513
2. Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells.  |  Donalies, M., et al. 1991. Proc Natl Acad Sci U S A. 88: 8024-8. PMID: 1840697
3. Single amino acid substitutions in one Ca2+ binding site of uvomorulin abolish the adhesive function.  |  Ozawa, M., et al. 1990. Cell. 63: 1033-8. PMID: 2257621
4. Localization of specificity determining sites in cadherin cell adhesion molecules.  |  Nose, A., et al. 1990. Cell. 61: 147-55. PMID: 2317870
5. M-cadherin-mediated intercellular interactions activate satellite cell division.  |  Marti, M., et al. 2013. J Cell Sci. 126: 5116-31. PMID: 24046443
6. Neural cadherin: role in selective cell-cell adhesion.  |  Miyatani, S., et al. 1989. Science. 245: 631-5. PMID: 2762814
7. Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family.  |  Hatta, K., et al. 1988. J Cell Biol. 106: 873-81. PMID: 2831236
8. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.  |  Takeichi, M. 1988. Development. 102: 639-55. PMID: 3048970
9. Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules.  |  Nose, A., et al. 1987. EMBO J. 6: 3655-61. PMID: 3428270
10. The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion.  |  Ringwald, M., et al. 1987. EMBO J. 6: 3647-53. PMID: 3501370
11. The cell adhesion molecule M-cadherin is specifically expressed in developing and regenerating, but not denervated skeletal muscle.  |  Moore, R. and Walsh, FS. 1993. Development. 117: 1409-20. PMID: 8404540
12. Involvement of M-cadherin in terminal differentiation of skeletal muscle cells.  |  Zeschnigk, M., et al. 1995. J Cell Sci. 108 (Pt 9): 2973-81. PMID: 8537437

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-M-cadherin Antibody (C-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-M-cadherin Antibody (C-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

M-cadherin Antibody (C-8) Specifications

Alternate Product Name: CDH15

Product Clone Name: C-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 710-727

Epitope Target: M-cadherin

Epitope Species: human

Product Reactivity/Detection: M-cadherin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for M-cadherin Antibody (C-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin