caspase-7 Antibody (Mch3 1-1-11): sc-56068
- caspase-7 Antibody (Mch3 1-1-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against full length caspase-7 of human origin
- recommended for detection of caspase-7 of mouse, rat and human origin by WB, IP and ELISA
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for caspase-7 Antibody (Mch3 1-1-11) for WB applications. These reagents are now offered in bundles with caspase-7 Antibody (Mch3 1-1-11) (see ordering information below).
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Caspase-7 Antibody (Mch3 1-1-11) is a mouse monoclonal IgG1 antibody that detects caspase-7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Caspase-7 is a crucial member of the Ced-3/caspase-1 family of cysteine proteases, which are integral to the apoptotic process, facilitating programmed cell death by cleaving specific target proteins that regulate cellular longevity. Notably, anti-caspase-7 antibody (Mch3 1-1-11) recognizes a protein known for cleaving poly(ADP-ribose) polymerase (PARP), a nuclear protein that plays a vital role in DNA repair and cellular stress responses. The cleavage of PARP by caspase-7 results in the generation of an apoptotic fragment, which is a hallmark of cells undergoing apoptosis. This process is essential for maintaining cellular homeostasis and preventing the propagation of damaged cells, thereby underscoring the importance of caspase-7 in both normal physiological processes and disease states. Caspase-7 monoclonal antibody (Mch3 1-1-11) serves as an invaluable tool for researchers investigating apoptosis and related pathways in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
caspase-7 Antibody (Mch3 1-1-11) References:
- Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. | Lamkanfi, M., et al. 2008. Mol Cell Proteomics. 7: 2350-63. PMID: 18667412
- Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors. | Rodríguez-Berriguete, G., et al. 2012. Hum Pathol. 43: 229-37. PMID: 21802116
- Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis. | Boucher, D., et al. 2012. Proc Natl Acad Sci U S A. 109: 5669-74. PMID: 22451931
- Caspase-7 in molar tooth development. | Matalova, E., et al. 2012. Arch Oral Biol. 57: 1474-81. PMID: 22858065
- Selective detection of caspase-3 versus caspase-7 using activity-based probes with key unnatural amino acids. | Vickers, CJ., et al. 2013. ACS Chem Biol. 8: 1558-66. PMID: 23614665
- Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. | Hill, ME., et al. 2016. ACS Chem Biol. 11: 1603-12. PMID: 27032039
- A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates. | Pham, B., et al. 2019. Biophys J. 117: 844-855. PMID: 31427065
- Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins. | Desroches, A. and Denault, JB. 2019. Proc Natl Acad Sci U S A. 116: 21521-21528. PMID: 31586028
- Cell death induction by Ranunculus ternatus extract is independent of mitochondria and dependent on Caspase-7. | Fang, M., et al. 2020. 3 Biotech. 10: 123. PMID: 32123647
- Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase‑7. | Kim, SH. and Baek, KH. 2022. Int J Oncol. 61: PMID: 36082810
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-7 Antibody (Mch3 1-1-11) | sc-56068 | 200 µg/ml | $316.00 | |||
caspase-7 Antibody (Mch3 1-1-11): m-IgGκ BP-HRP Bundle | sc-534283 | 200 µg Ab; 40 µg BP | $354.00 | |||
caspase-7 Antibody (Mch3 1-1-11): m-IgG1 BP-HRP Bundle | sc-538863 | 200 µg Ab; 20 µg BP | $354.00 |