COL18A1 Antibody (F-6): sc-514355

COL18A1 Antibody (F-6) is a mouse monoclonal IgG1 antibody that detects Collagen Type XVIII (COL18A1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-COL18A1 antibody (F-6) specifically targets COL18A1, a member of the MULTIPLEXIN subgroup of collagens, which is characterized by unique structure including multiple triple-helical domains interspersed with non-triple-helical regions. This structural arrangement allows COL18A1 to play significant roles in various biological processes, including basement membrane formation and angiogenesis regulation. COL18A1 produces endostatin, a fragment that inhibits angiogenesis and tumor growth, highlighting COL18A1′s importance in cancer biology and tissue homeostasis. COL18A1 is predominantly expressed in the liver, heart, kidney, and other vital organs, indicating essential functions in maintaining tissue integrity. COL18A1′s ability to interact with various signaling molecules further underscores roles in cellular communication and tissue repair mechanisms. With diverse applications and critical biological relevance, COL18A1 monoclonal antibody (F-6) serves as an invaluable tool for researchers studying collagen′s intricate roles in health and disease.

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COL18A1 Antibody (F-6) References:

1. A high risk of occurrence of sporadic breast cancer in individuals with the 104NN polymorphism of the COL18A1 gene.  |  Lourenço, GJ., et al. 2006. Breast Cancer Res Treat. 100: 335-8. PMID: 16807676
2. COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C > T in its 'frizzled' motif is associated with obesity in diabetes type 2 patients.  |  Errera, FI., et al. 2008. An Acad Bras Cienc. 80: 167-77. PMID: 18345385
3. Genetic polymorphisms in COL18A1 influence the development of osteosarcoma.  |  Guo, Z., et al. 2015. Int J Clin Exp Pathol. 8: 11531-6. PMID: 26617886
4. Familial epilepsy with anterior polymicrogyria as a presentation of COL18A1 mutations.  |  Corbett, MA., et al. 2017. Eur J Med Genet. 60: 437-443. PMID: 28602933
5. COL18A1 is a candidate eye iridocorneal angle-closure gene in humans.  |  Suri, F., et al. 2018. Hum Mol Genet. 27: 3772-3786. PMID: 30007336
6. Functional Impact of Human Genetic Variants of COL18A1/Endostatin on Pulmonary Endothelium.  |  Goyanes, AM., et al. 2020. Am J Respir Cell Mol Biol. 62: 524-534. PMID: 31922883
7. Variable phenotype of Knobloch syndrome due to biallelic COL18A1 mutations in children.  |  Levinger, N., et al. 2021. Eur J Ophthalmol. 31: 3349-3354. PMID: 33238767
8. Mutations in the COL18A1 gen associated with knobloch syndrome and structural brain anomalies: a novel case report and literature review of neuroimaging findings.  |  Irene Díez García-Prieto, I., et al. 2022. Neurocase. 28: 11-18. PMID: 35253627
9. Restoring the epigenetically silenced lncRNA COL18A1-AS1 represses ccRCC progression by lipid browning via miR-1286/KLF12 axis.  |  Liu, Y., et al. 2022. Cell Death Dis. 13: 578. PMID: 35787628
10. Generation of an induced pluripotent stem cell line (ZSZOCi001-A) from a patient with Knobloch syndrome caused by biallelic mutations in the gene COL18A1.  |  Jiang, Z., et al. 2023. Stem Cell Res. 70: 103131. PMID: 37269665

The preferred COL18A1 antibody is COL18A1 Antibody (1837-46): sc-32720.