COL3A1 Antibody (B-10): sc-271249

COL3A1 Antibody (B-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects COL3A1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-COL3A1 antibody (B-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. COL3A1, also known as collagen type III alpha 1 chain, plays a crucial role in the structural integrity of connective tissues, particularly in tissues that require flexibility and resilience, such as skin, blood vessels, and internal organs. COL3A1 unique triple helix structure allows for the formation of fibrils that provide tensile strength, while COL3A1 ability to interact with other collagen types and extracellular matrix components is vital for maintaining tissue architecture and function. Additionally, COL3A1 is often involved in wound healing and tissue repair processes, making COL3A1 an important target for research in fibrosis and other connective tissue disorders. anti-COL3A1 antibody (B-10) versatility in various applications makes anti-COL3A1 antibody (B-10) an essential tool for researchers studying the dynamics of collagen in health and disease.

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COL3A1 Antibody (B-10) References:

1. Collagen and bone strength.  |  Boskey, AL., et al. 1999. J Bone Miner Res. 14: 330-5. PMID: 10027897
2. Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways.  |  Alberio, L. and Dale, GL. 1999. Eur J Clin Invest. 29: 1066-76. PMID: 10583456
3. The type of variants at the COL3A1 gene associates with the phenotype and severity of vascular Ehlers-Danlos syndrome.  |  Frank, M., et al. 2015. Eur J Hum Genet. 23: 1657-64. PMID: 25758994
4. Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases.  |  Kuivaniemi, H. and Tromp, G. 2019. Gene. 707: 151-171. PMID: 31075413
5. Phenotype of COL3A1/COL5A2 deletion patients.  |  Kempers, MJ., et al. 2022. Eur J Med Genet. 65: 104593. PMID: 35964930
6. COL3A1 Overexpression Associates with Poor Prognosis and Cisplatin Resistance in Lung Cancer.  |  Wang, L., et al. 2022. Balkan Med J. 39: 393-400. PMID: 36148899
7. An integrated analysis of bulk and single-cell sequencing data reveals that EMP1+/COL3A1+ fibroblasts contribute to the bone metastasis process in breast, prostate, and renal cancers.  |  Du, H., et al. 2023. Front Immunol. 14: 1313536. PMID: 38187400
8. Role and mechanism of COL3A1 in regulating the growth, metastasis, and drug sensitivity in cisplatin-resistant non-small cell lung cancer cells.  |  Ren, J., et al. 2024. Cancer Biol Ther. 25: 2328382. PMID: 38530094
9. Cell adhesion to collagenous matrices.  |  McCarthy, JB., et al. 1996. Biopolymers. 40: 371-81. PMID: 8765608
10. Versatile collagens in invertebrates.  |  Engel, J. 1997. Science. 277: 1785-6. PMID: 9324767
11. The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease.  |  Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COL3A1 Antibody (B-10) has 82 citations in a variety of scientific publications.

Primary antibodies like Anti-COL3A1 Antibody (B-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COL3A1 Antibody (B-10) Specifications

Alternate Product Name: COL3A1

Product Clone Name: B-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 901-1200

Epitope Target: Collagen α1 Type III

Epitope Species: human

Product Reactivity/Detection: Collagen α1 Type III

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 82 citations in various scientific publications

Available Conjugates/Forms for COL3A1 Antibody (B-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Pro-COL3A1 antibody is Pro-COL3A1 Antibody (B-4): sc-166316.