COL6A1 Antibody (B-4): sc-377143

COL6A1 Antibody (B-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects COL6A1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-COL6A1 antibody (B-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. COL6A1, a crucial component of collagen type VI, plays a significant role in the structural integrity of the extracellular matrix, particularly in connective tissues such as tendons and cartilage. A unique triple helix structure allows for the formation of stable fibrils, which are essential for providing tensile strength and elasticity to tissues. COL6A1 is involved in cell adhesion processes, which are vital for maintaining normal tissue architecture and function. Disruptions in COL6A1 expression or function can lead to various connective tissue disorders, highlighting COL6A1′s importance in both health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

COL6A1 Antibody (B-4) References:

1. Collagen and bone strength.  |  Boskey, AL., et al. 1999. J Bone Miner Res. 14: 330-5. PMID: 10027897
2. Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways.  |  Alberio, L. and Dale, GL. 1999. Eur J Clin Invest. 29: 1066-76. PMID: 10583456
3. Pathological characteristics of skeletal muscle in Ullrich's disease with collagen VI deficiency.  |  Higuchi, I., et al. 2003. Neuromuscul Disord. 13: 310-6. PMID: 12868500
4. Collagen type VI expression during cardiac development and in human fetuses with trisomy 21.  |  Gittenberger-de Groot, AC., et al. 2003. Anat Rec A Discov Mol Cell Evol Biol. 275: 1109-16. PMID: 14613310
5. Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency.  |  Irwin, WA., et al. 2003. Nat Genet. 35: 367-71. PMID: 14625552
6. Modulation of collagen fibrillogenesis by tenascin-X and type VI collagen.  |  Minamitani, T., et al. 2004. Exp Cell Res. 298: 305-15. PMID: 15242785
7. Position of glycine substitutions in the triple helix of COL6A1, COL6A2, and COL6A3 is correlated with severity and mode of inheritance in collagen VI myopathies.  |  Butterfield, RJ., et al. 2013. Hum Mutat. 34: 1558-67. PMID: 24038877
8. H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts.  |  Zhang, Y., et al. 2021. Theranostics. 11: 1473-1492. PMID: 33391546
9. The recurrent deep intronic pseudoexon-inducing variant COL6A1 c.930+189C>T results in a consistently severe phenotype of COL6-related dystrophy: Towards clinical trial readiness for splice-modulating therapy.  |  Foley, AR., et al. 2024. medRxiv.. PMID: 38585825
10. Cell adhesion to collagenous matrices.  |  McCarthy, JB., et al. 1996. Biopolymers. 40: 371-81. PMID: 8765608
11. Versatile collagens in invertebrates.  |  Engel, J. 1997. Science. 277: 1785-6. PMID: 9324767
12. The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease.  |  Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COL6A1 Antibody (B-4) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-COL6A1 Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COL6A1 Antibody (B-4) Specifications

Alternate Product Name: COL6A1

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 53-87

Epitope Target: Collagen α1 Type VI

Epitope Species: mouse

Product Reactivity/Detection: Collagen α1 Type VI

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for COL6A1 Antibody (B-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin