caspase-9 Antibody (9CSP01): sc-81663
- caspase-9 Antibody (9CSP01) is a mouse monoclonal IgG1 κ, cited in 18 publications, provided at 200 µg/ml
- raised against full-length recombinant caspase-9 of human origin
- recommended for detection of caspase-9 of mouse, rat and human origin by WB and IP
- See caspase-9 (96.1.23): sc-56076 for caspase-9 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for caspase-9 Antibody (9CSP01) for WB applications. These reagents are now offered in bundles with caspase-9 Antibody (9CSP01) (see ordering information below).
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caspase-9 Antibody (9CSP01) is a mouse monoclonal IgG1 antibody that detects caspase-9 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Caspase-9 plays a pivotal role in the intrinsic pathway of apoptosis, acting as an initiator caspase that is activated in response to cellular stress and damage. Upon activation, caspase-9 cleaves and activates downstream effector caspases, such as caspase-3 and caspase-7, leading to the execution phase of apoptosis. This process is crucial for maintaining cellular homeostasis and preventing the proliferation of damaged or potentially cancerous cells. The activation of caspase-9 is tightly regulated and can be influenced by various factors, including the presence of apoptosomes, which are complexes formed in response to cytochrome c release from mitochondria. The ability of caspase-9 to integrate signals from both intrinsic and extrinsic apoptotic pathways underscores its importance in cellular decision-making processes regarding survival and programmed cell death. Anti-caspase-9 antibody (9CSP01) is an essential tool for researchers studying apoptosis and its implications in various diseases, including cancer and neurodegenerative disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
caspase-9 Antibody (9CSP01) References:
- Pre-processed caspase-9 contained in mitochondria participates in apoptosis. | Costantini, P., et al. 2002. Cell Death Differ. 9: 82-8. PMID: 11803376
- Caspase-9 takes part in programmed cell death in developing mouse kidney. | Araki, T., et al. 2003. Nephron Exp Nephrol. 93: e117-24. PMID: 12660414
- Caspase-9 activation in hypoxic human corneal epithelial cells. | Kurpakus-Wheater, M., et al. 2003. Apoptosis. 8: 681-8. PMID: 14739614
- Caspase-9-dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, BAX, and caspase 2. | Lysiak, JJ., et al. 2007. Cell Tissue Res. 328: 411-9. PMID: 17265069
- Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis. | Lafont, E., et al. 2012. Biochim Biophys Acta. 1821: 684-93. PMID: 22306364
- Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface. | Huber, KL., et al. 2012. Biopolymers. 98: 451-65. PMID: 23203690
- Effect of caspase-9 inhibition on endoplasmic reticulum stress induced cortical neuronal injury in rats. | Zhang, H., et al. 2013. Int J Clin Exp Med. 6: 546-51. PMID: 23936593
- Effects of Caspase 9 Gene Polymorphism in Patients with Prostate Cancer. | Yilmaz, SG., et al. 2017. In Vivo. 31: 205-208. PMID: 28358701
- miR-1269 promotes cell survival and proliferation by targeting tp53 and caspase-9 in lung cancer. | Bao, M., et al. 2018. Onco Targets Ther. 11: 1721-1732. PMID: 29618932
- MicroRNA-378 inhibits hepatocyte apoptosis during acute liver failure by targeting caspase-9 in mice. | Feng, Z., et al. 2023. Gastroenterol Hepatol. 46: 124-134. PMID: 35964807
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-9 Antibody (9CSP01) | sc-81663 | 200 µg/ml | $316.00 | |||
caspase-9 Antibody (9CSP01): m-IgG Fc BP-HRP Bundle | sc-537256 | 200 µg Ab; 10 µg BP | $354.00 | |||
caspase-9 Antibody (9CSP01): m-IgGκ BP-HRP Bundle | sc-534481 | 200 µg Ab; 40 µg BP | $354.00 | |||
caspase-9 Antibody (9CSP01): m-IgG1 BP-HRP Bundle | sc-545111 | 200 µg Ab; 20 µg BP | $354.00 |