caspase-9 Antibody (LAP 96-2-22): sc-56077

Caspase-9 Antibody (LAP 96-2-22) is a mouse monoclonal IgG1 antibody that detects caspase-9 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Caspase-9 plays a pivotal role in the intrinsic pathway of apoptosis, acting as an initiator caspase that is activated in response to cellular stress and damage. Upon activation, caspase-9 cleaves and activates downstream effector caspases, such as caspase-3 and caspase-7, leading to the execution phase of apoptosis, which is crucial for maintaining cellular homeostasis and eliminating damaged or unwanted cells. Proper functioning of caspase-9 is essential for preventing uncontrolled cell proliferation and has significant implications in cancer biology, where dysregulation of apoptotic pathways can contribute to tumorigenesis. Caspase-9 is located in the cytosol and is recruited to the apoptosome, a multiprotein complex formed in response to apoptotic signals, highlighting its importance in the cellular response to stress. The ability of caspase-9 to integrate various pro-apoptotic signals makes caspase-9 a critical target for therapeutic interventions aimed at restoring apoptosis in cancer cells. Anti-caspase-9 antibody (LAP 96-2-22) is an invaluable tool for researchers studying apoptosis and its implications in various diseases, providing insights into the mechanisms of cell death and survival.

The preferred caspase-9 antibody is caspase-9 Antibody (96.1.23): sc-56076.