Integrin αL/ITGAL/CD11a Antibody (E-1): sc-374172

Integrin αL Antibody (E-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects Integrin alpha L protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Integrin αL antibody (E-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrin alpha L protein, also known as ITGAL or CD11A, plays a crucial role in immune response by mediating leukocyte adhesion to endothelial cells, which is essential for immune cell migration to sites of inflammation or injury. This process enables leukocytes to exit the bloodstream and infiltrate tissues where they can perform functions, such as fighting infections or repairing damaged tissue. Integrins, including Integrin alpha L, are heterodimers composed of noncovalently associated transmembrane α and β subunits, and these receptors bind to various ligands, such as intracellular adhesion molecules (ICAMs), which is critical for cell-cell interactions and signaling pathways that regulate immune responses. Integrin αL (E-1) antibody serves as a valuable tool for researchers studying mechanisms of immune cell adhesion and migration, providing insights into both normal physiological processes and pathological conditions such as autoimmune diseases and cancer.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Integrin αL/ITGAL/CD11a Antibody (E-1) References:

1. Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter.  |  Zhang, Z., et al. 2002. Mech Ageing Dev. 123: 1257-68. PMID: 12020947
2. Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2.  |  Rose, DM., et al. 2003. J Immunol. 170: 5912-8. PMID: 12794117
3. The integrin alpha L beta 2 hybrid domain serves as a link for the propagation of activation signal from its stalk regions to the I-like domain.  |  Tng, E., et al. 2004. J Biol Chem. 279: 54334-9. PMID: 15456774
4. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
5. The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.  |  Kim, M., et al. 2004. J Cell Biol. 167: 1241-53. PMID: 15611342
6. Adhesion molecules CD11a, CD18, and ICAM-1 on human epidermal Langerhans cells serve a functional role in the activation of alloreactive T cells.  |  Simon, JC., et al. 1991. J Invest Dermatol. 96: 148-51. PMID: 1670950
7. Aggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for cytotoxicity.  |  Kieba, IR., et al. 2007. Cell Microbiol. 9: 2689-99. PMID: 17587330
8. The integrin αL leg region controls the Mg/EGTA mediated activation of LFA-1.  |  Guan, S., et al. 2015. Biochem Biophys Res Commun. 458: 251-5. PMID: 25640842
9. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
10. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
11. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
12. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin αL/ITGAL/CD11a Antibody (E-1) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin αL/ITGAL/CD11a Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin αL/ITGAL/CD11a Antibody (E-1) Specifications

Alternate Product Name: Integrin αL

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 801-1100

Epitope Target: Integrin αL

Epitope Species: human

Product Reactivity/Detection: Integrin αL

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Integrin αL/ITGAL/CD11a Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin