Integrin αM/CD11b Antibody (VIM12): sc-59744
- Integrin αM/CD11b Antibody (VIM12) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against the heavily glycosylated portion of the C-terminal region of Integrin αM of human origin
- recommended for detection of Integrin αM heterodimer present on natural killer cells, monocytes and granulocytes of human origin by IF, IHC(P) and FCM
- See Integrin αM/CD11b (2LPM19c): sc-20050 for Integrin αM/CD11b antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Integrin αM/CD11b Antibody (VIM12) for IHC(P) applications. These reagents are now offered in bundles with Integrin αM/CD11b Antibody (VIM12) (see ordering information below).
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Integrin αM Antibody (VIM12) is a mouse monoclonal IgG1 kappa antibody designed to recognize the heavily glycosylated C-terminal region of Integrin αM, also known as CD11b, ITGAM, Mac-1 α subunit, and complement component receptor-3 α. Integrin αM monoclonal antibody (VIM12) demonstrates strong reactivity with the Integrin αM heterodimer present on natural killer cells, monocytes, and granulocytes of human origin, making anti-Integrin αM antibody (VIM12) an essential tool for applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Integrin αM is a subunit of a heterodimeric complex, partnering with the β2 chain (CD18) to form the Mac-1 complex, which is crucial for cell adhesion and migration. The precise structure of Integrin αM allows for mediating critical interactions between immune cells and the extracellular matrix, facilitating processes like cell migration, phagocytosis, and the regulation of immune responses. By binding to intracellular adhesion molecules (ICAMs) and other ligands, Integrin αM plays a pivotal role in the adherence and activation of immune cells during inflammatory responses. Understanding the structural nuances of Integrin αM is vital for elucidating its function in immune cell trafficking and the molecular mechanisms underlying various immune-related diseases. Integrin αM monoclonal antibody (VIM12) enables researchers to investigate the distribution and expression levels of Integrin αM in different cell types, thereby contributing to advancements in immunology and the development of therapeutic interventions targeting inflammatory and immune disorders. Anti-Integrin αM antibody (VIM12) serves as an indispensable reagent for scientists exploring the structural and functional aspects of Integrin αM in human immune cells, providing reliable and specific detection to enhance experimental outcomes and support breakthroughs in immunological research.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin αM/CD11b Antibody (VIM12) | sc-59744 | 200 µg/ml | $316.00 | |||
Integrin αM/CD11b Antibody (VIM12): m-IgG Fc BP-HRP Bundle | sc-539138 | 200 µg Ab; 10 µg BP | $354.00 | |||
Integrin αM/CD11b Antibody (VIM12): m-IgG1 BP-HRP Bundle | sc-541286 | 200 µg Ab; 20 µg BP | $354.00 |